Palladium-catalyzed carbonylative cyclization of benzyl chlorides with anthranils for the synthesis of 3-arylquinolin-2(1H)-ones

An efficient carbonylative procedure for the synthesis of 3-arylquinoin-2(1H)-ones has been established. Through a palladium-catalyzed aminocarbonylation of benzyl chlorides with anthranils, a variety of 3-arylquinoin-2(1H)-one products were obtained in moderate to excellent yields with good functional group tolerance.

Automated summary

An efficient carbonylative procedure has been developed for the synthesis of 3-arylquinoin-2(1H)-ones. The products were obtained in moderate to excellent yields with good functional group tolerance through a palladium-catalyzed aminocarbonylation reaction of benzyl chlorides with anthranils.