One-Pot Domino Henry-Friedel-Crafts Alkylation Reaction in Deep Eutectic Solvent

A green multicomponent reaction between aldehydes, nitromethane and N-substituted anilines in deep eutectic solvent (DES) has been developed. In this reaction, aldehydes and nitromethane underwent Henry reaction, followed by a Friedel-Crafts alkylation reaction with electron-rich arenes. The desired products were formed quickly in excellent yields under mild conditions without the need of any additional catalysts. The deep eutectic solvent (zinc chloride and choline chloride) is cheap and recyclable, which reduces the synthesis cost.

Automated summary

A green multicomponent reaction using a deep eutectic solvent (DES) has been developed, resulting in high yields of desired products without the need for additional catalysts. The DES, composed of zinc chloride and choline chloride, is cost-effective and recyclable, reducing the synthesis cost.