Journal
ACTA DERMATO-VENEREOLOGICA
Volume 101, Issue -, Pages -Publisher
ACTA DERMATO-VENEREOLOGICA
DOI: 10.2340/00015555-3737
Keywords
hidradenitis suppurativa; survival analysis; prescription; comorbidity; analgesia; antidepressants
Categories
Funding
- Leo Foundation [LF 18002]
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A study on symptoms of hidradenitis suppurativa in blood donors found an increased hazard ratio for antidepressants and analgesics in those reporting symptoms of the disease. Pain and depression were identified as the earliest comorbidities to present in the pathogenesis of the disease.
Hidradenitis suppurativa is a common recurrent inflammatory skin disease. It is associated with multiple comorbidities whose temporal relationships are unknown due to long diagnostic delays. This study of otherwise healthy blood donors with self-reported symptoms of hidradenitis suppurativa investigated the temporal relationships of comorbidities. A prospective survival analysis on a nationwide cohort of blood donors, using registry data on drug prescription, was used to calculate the hazard ratio of time until first prescription of medical treatment for the following hidradenitis suppurativa-related comorbidities: heart disease, diabetes, depression, thyroid disease and pain. Hidradenitis suppurativa status was determined by a validated questionnaire, and the survival analysis was adjusted for age, sex, body mass index, smoking status and having an International Classification of Diseases Version 10 (ICD-10) diagnosis of hidradenitis suppurativa. Of the participants, 1,012 reported hidradenitis suppurativa symptoms, and these symptoms increased the hazard ratio of antidepressants (1.73, 95% confidence interval 1.17-2.56, p approximate to 0.006) and analgesics (hazard ratio 1.24, 95% confidence interval 1.11-1.39, p < 0.001). Pain and depression are the first comorbidities to present in hidradenitis suppurativa pathogenesis.
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