Journal
INORGANIC CHEMISTRY FRONTIERS
Volume 8, Issue 10, Pages 2624-2633Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1qi00252j
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Funding
- National Natural Science Foundation of China [NSFC 51720105015, 51672269, 51929201, 51922097, 51772124, 51872282]
- Chinese Government [2017YFE0132300]
- Australian Government [2017YFE0132300]
- Major Program of Basic Research and Applied Research of Guangdong Province [2017KZDXM083]
- Key Research Program of Frontier Sciences, CAS [YZDYSSW-JSC018]
- Youth Innovation Promotion Association of CAS [2017273]
- Overseas, Hong Kong & Macao Scholars Collaborated Researching Fund [21728101]
- CAS-Croucher Funding Scheme for Joint Laboratories [CAS18204]
- Jiangmen Innovative Research Team Program (2017)
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A new nano-composite UCZRF was designed to release photosensitizer and metal ions specifically in the tumor microenvironment, effectively enhancing the efficiency of ROS generation, and thus strengthening the anti-tumor effects of CDT and PDT.
The generation of reactive oxygen species (ROS) is often limited by the overexpression of glutathione (GSH) in the tumor microenvironment (TME) and the penetration depth of visible light. In view of this, we designed biodegradable Cu/ZIF-8 shell-coated lanthanide-doped nanoparticles and loaded with a photosensitizer (Rose Bengal), and fabricated a NIR-triggered nanocomposite NaYF4:20%Yb, 2%Er@Cu/ZIF-8/RB@F127 (UCZRF) for the synergistic treatment of CDT and PDT. Interestingly, the UCZRF nanostructures can specifically release RB and Cu2+ in the acidic tumor microenvironment (TME). Cu2+ depletes GSH to effectively change the amount of ROS produced by RB under 980 nm laser irradiation, and Cu+ from the reduction reaction of GSH reacts with excess hydrogen peroxide (H2O2) in the TME to generate hydroxyl radicals (OH) with high oxidation activity. In such a simple nanosystem, we enhance the anti-tumor effect of CDT and PDT by improving the efficiency of ROS generation.
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