Journal
FOOD HYDROCOLLOIDS
Volume 86, Issue -, Pages 34-42Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodhyd.2017.12.026
Keywords
Type 2 diabetes; Polysaccharide; Plantago asiatica L.; Colon microbiota; Short-chain fatty acids
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Funding
- National Natural Science Foundation of China for Excellent Young Scholars [31422042]
- Outstanding Science and Technology Innovation Team Project in Jiangxi Province [20165BCB19001]
- Project of Academic Leaders of the Major Disciplines in Jiangxi Province [20162BCB22008]
- Collaborative Project in Agriculture and Food Field between China and Canada [2017ZJGH0102001]
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Type 2 diabetes is a complex metabolic and endocrine disorder worldwide, which causes severe health and economic problems. The effects of polysaccharide from Plantago asiatica L. (PLP) on high-fat diet and streptozotocin-induced type 2 diabetic rats were examined. Administration of PLP caused significant decreases in the concentrations of blood glucose, insulin, total cholesterol, triglyceride, non-esterified fatty acid and maleic dialdehyde, and significant increases in the levels of high density lipoprotein-cholesterol and the activities of antioxidant enzymes compared with diabetic rats after 4 weeks' treatment. The concentrations of short-chain fatty acids (SCFA) were significantly higher in the feces of diabetic rats after treatment with PLP. Moreover, colon bacterial diversity and abundance of bacteria, including Bacteroides vulgatus, Lactobacillus fermentum, Prevotella loescheii and Bacteroides vulgates were significantly increased by PLP treatment. These results indicated that the anti-diabetic effect of PLP in type 2 diabetic rats may be associated with regulation of gut microbiota and increased levels of SCFA. (C) 2017 Elsevier Ltd. All rights reserved.
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