Journal
RADIOLOGY AND ONCOLOGY
Volume 55, Issue 1, Pages 97-105Publisher
WALTER DE GRUYTER GMBH
DOI: 10.2478/raon-2020-0062
Keywords
antioxidant; male infertility; oligo-astheno-teratozoospermia; semen quality; DNA fragmentation; cancer
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This study found that the oral intake of astaxanthin did not affect any semen parameters in patients with oligospermia with/without asthenozoospermia or teratozoospermia.
Background. Higher concentrations of seminal reactive oxygen species may be related to male infertility. Astaxanthin with high antioxidant activity can have an impact on the prevention and treatment of various health conditions, including cancer. However, efficacy studies on astaxanthin in patients with oligosperrnia with/without astheno- or teratozoospermia (O +/- A +/- T) have not yet been reported. Our aim was to evaluate the effect of the oral intake of astaxanthin on semen parameters. Patients and methods. In a randomized double-blind trial, 80 men with O +/- A +/- T were allocated to intervention with 16 mg astaxanthin orally daily or placebo. At baseline and after three months basic semen parameters, sperm deoxyribonucleic acid (DNA) fragmentation and mitochondrial membrane potential (MMP) of spermatozoa and serum follicle-stimulating hormone (FSH) value were measured. Results. Analysis of the results of 72 patients completing the study (37 in the study group, 35 in the placebo group) did not show any statistically significant change, in the astaxanthin group no improvements in the total number of spermatozoa, concentration of spermatozoa, total motility of spermatozoa, morphology of spermatozoa, DNA fragmentation and mitochondria! membrane potential of spermatozoa or serum FSH were determined. In the placebo group, statistically significant changes in the total number and concentration of spermatozoa were determined. Conclusions. The oral intake of astaxanthin did not affect any semen parameters in patients with O +/- A +/- T.
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