Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 41, Pages 5040-5042Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc01062j
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Funding
- National Natural Science Foundation of China [22022707, 21778078, 21837006]
- innovative team of Ministry of Education [IRT_17R111]
- Fundamental Research Funds for the Central Universities
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In this study, a neutral iridium complex with viscosity-responsive phosphorescent emission intensity and lifetime was reported. Quantitative measurement using two-photon phosphorescent lifetime imaging revealed significant viscosity increase of ER during erastin-induced ferroptosis. This work offers an effective strategy for quantitatively measuring micro-environmental alterations of subcellular organelles during a specific cell death process.
Herein, we report a neutral iridium complex, [Ir(4-(2-pyridinyl)benzaldehyde)(2)(acetylacetone)] (Ir-ER), with viscosity-responsive phosphorescent emission intensity and lifetime. Quantitative measurement by two-photon phosphorescent lifetime imaging shows that the viscosity of ER increases significantly in the process of erastin-induced ferroptosis. Our work provides an effective strategy for quantitative measurement of the micro-environmental alternations of subcellular organelles during a specific cell death process.
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