Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 9, Issue 11, Pages 2727-2735Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0tb02305a
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Funding
- National Natural Science Foundation of China [21736006, 21908103, 81870396]
- Natural Science Foundation of Jiangsu Province [BK20190674]
- Fund of State Key Laboratory of Materials-Oriented Chemical Engineering [ZK201704, ZK201809]
- Social Development Projects for Key Research and Development Plan in Jiangsu Province [BE2017725]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Jiangsu Specially-Appointed Professor Program
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The preparation of dual-release pharmaceutical microfibers in this study provides an ideal material for new biomedical applications. By engineering heterotypic bead-on-string fibers with the ability to carry dual cargos and to deliver on demand, the microfibers show positive effects in promoting wound healing.
The preparation of dual-release pharmaceutical microfibers provides an ideal material for new biomedical applications. We describe a microfluidic spinning method for engineering heterotypic bead-on-string fibers with the ability to carry dual cargos and to deliver on demand. The core of our technology is to combine microfluidic spinning with biomaterial preparation, in which hydrophobic and hydrophilic cargos can be integrated into a bead-on-string microfiber structure. We demonstrate the loading of bovine serum albumin (BSA) in the sodium alginate phase and ibuprofen in the polylactic acid (PLA) phase, respectively. The heterotypic bead-on-string fibers are biocompatible and show hemostatic ability in vivo. These heterotypic bead-on-string fibers are then woven as a skin scaffold and shown to promote wound healing by loading antibacterial and anti-inflammatory cargos.
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