Journal
NATURE CANCER
Volume 2, Issue 3, Pages 258-270Publisher
NATURE PORTFOLIO
DOI: 10.1038/s43018-021-00181-0
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Funding
- Brewster Foundation
- American Cancer Society
- Susan G. Komen Foundation
- Breast Cancer Research Foundation
- NIH
- US Department of Defense
- NCI
- Hugs for Brady
- AHEPA
- Val Skinner Foundation
- Gertrude Fogarty Trust
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The systemic spread of tumor cells is the major cause of cancer deaths, with few effective therapeutic strategies targeting metastasis. Recent advances in understanding tumor-intrinsic pathways, immune-activating strategies, and emerging areas offer potential for innovative treatments against metastatic cancer. Kang and colleagues review recent progress and challenges in developing therapies for metastatic disease and discuss the clinical implications of ongoing and completed studies.
The systemic spread of tumor cells is the ultimate cause of the majority of deaths from cancer, yet few successful therapeutic strategies have emerged to specifically target metastasis. Here we discuss recent advances in our understanding of tumor-intrinsic pathways driving metastatic colonization and therapeutic resistance, as well as immune-activating strategies to target metastatic disease. We focus on therapeutically exploitable mechanisms, promising strategies in preclinical and clinical development, and emerging areas with potential to become innovative treatments. Kang and colleagues review recent advances and challenges in developing therapies for metastatic cancer and the clinical implications of ongoing and completed studies for metastatic disease.
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