Journal
ANALYST
Volume 146, Issue 4, Pages 1169-1177Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0an02172e
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Funding
- Swedish Research Council
- Sahlgrenska University Hospital
- University Hospital ALF research grants
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By utilizing cluster ion beam ToF-SIMS and/or MALDI-ToF mass spectrometry imaging, along with classical- or immuno-histochemical staining, a new multimodal chemical imaging workflow was established for correlation analysis between lipid molecular ion images and immuno/histological features within the cerebellum region of the same brain tissue section.
Cluster ion beam ToF-SIMS and/or MALDI-ToF mass spectrometry imaging (using 1,5-DAN matrix via sublimation) of a single coronal rat brain tissue section followed by classical- or immuno- histochemical staining faclilated a new multimodal chemical imaging workflow allowing complementary correlation of the lipid molecular ion images with the immuno/histological features within cerebellum region of the same brain tisue section.
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