Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 8, Issue 7, Pages 1466-1473Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0qo01519a
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Funding
- National Key Research and Development Program of China [2019YFC0312503, 2017YFC0506300]
- National Natural Science Foundation of China [41476136, 41890853, 41776169]
- Guangdong Provincial Special Fund for Marine Economic Development Project (Yue Natural Resources) [[2020]042]
- Pearl River S&T Nova Program of Guangzhou [201710010136]
- Guangzhou Branch of the Supercomputing Center of Chinese Academy of Sciences
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Euroticins C-E, three pairs of salicylaldehyde derivative enantiomers, were isolated from a marine-derived fungus Eurotium sp. SCSIO F452. They exhibit highly constructed tetracyclic structures and show significant antioxidative activity and moderate cytotoxic activity.
Euroticins C-E (1-3), three pairs of salicylaldehyde derivative enantiomers, were isolated from a marine-derived fungus Eurotium sp. SCSIO F452. They represent two types of salicylaldehyde derivatives bearing unprecedented highly constructed 6/6/6/6 tetracyclic structures. Their structures were established by comprehensive spectroscopic analyses, X-ray diffraction, and electronic circular dichroism calculations. Compounds (+)-1 and (-)-1 showed significant antioxidative activity and moderate cytotoxic activity.
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