Journal
FOOD CHEMISTRY
Volume 234, Issue -, Pages 408-415Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2017.05.032
Keywords
N-nitrosamines; Dispersive liquid-liquid microextraction; High-performance liquid chromatography; Fluorescent labeling
Funding
- National Natural Science Foundation of China [21677085, 21537001, 81472986]
- China Postdoctoral Science Foundation [2016M590071]
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The intake of N-nitrosamines (NAs) from foodstuffs is considered to be an important influence factor for several cancers. But the rapid and sensitive screening of NAs remains a challenge in the field of food safety. Inspired by that, a sensitive and rapid method was demonstrated for determination of five NAs (Nitrosopyrrolidine, Nitrosodimethylamine, Nitrosodiethylamine, Nitrosodipropylamine and Nitrosodibutylamine) using dispersive liquid-liquid microextraction (DLLME) followed by high-performance liquid chromatography with fluorescence detection (HPLC-FLD). The NM were firstly denitrosated and labeled by 2-(11H-benzo[a]carbazol-11-yl) ethyl carbonochloridate (BCEC-Cl) and finally enriched by DLLME. Furthermore, the main DLLME conditions were optimized systematically. Under the optimal conditions, satisfactory limits of detection (LODs) were obtained with a range of 0.01-0.07 ng g(-1), which were significantly lower than the reported methods. The developed method showed many merits including rapidity, simplicity, high sensitivity and excellent selectivity, which shows a broad prospect in food safety analysis. (C) 2017 Elsevier Ltd. All rights reserved.
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