Journal
EUROPACE
Volume 23, Issue 1, Pages 139-146Publisher
OXFORD UNIV PRESS
DOI: 10.1093/europace/euaa243
Keywords
Catheter ablation; Irreversible electroporation; Gaseous microemboli; Myocardial damage; Embolic stroke
Categories
Funding
- Abbott Laboratories
- Abbott Park, IL, USA
Ask authors/readers for more resources
Anodal IRE applications result in significantly less gas formation compared to cathodal IRE applications and RF applications, which is supported by transoesophageal echocardiography observations.
Aims Irreversible electroporation (IRE) ablation is a non-thermal ablation method based on the application of direct current between a multi-electrode catheter and skin electrode. The delivery of current through blood leads to electrolysis. Some studies suggest that gaseous (micro)emboli might be associated with myocardial damage and/or (a)symptomatic cerebral ischaemic events. The aim of this study was to compare the amount of gas generated during IRE ablation and during radiofrequency (RF) ablation. Methods and results In six 60-75 kg pigs, an extracorporeal femoral shunt was outfitted with a bubble-counter to detect the size and total volume of gas bubbles. Anodal and cathodal 200J IRE applications were delivered in the left atrium (LA) using a 14-electrode circular catheter. The 30 and 60 s 40W RF point-by-point ablations were performed. Using transoesophageal echocardiography (TOE), gas formation was visualized. Average gas volumes were 0.6 +/- 0.6 and 56.9 +/- 19.1 mu L (P< 0.01) for each anodal and cathodal IRE application, respectively. Also, qualitative TOE imaging showed significantly less LA bubble contrast with anodal than with cathodal applications. Radiofrequency ablations produced 1.7 +/- 2.9 and 6.7 +/- 7.4 mu L of gas, for 30 and 60 s ablation time, respectively. Conclusion Anodal IRE applications result in significantly less gas formation than both cathodal IRE applications and RF applications. This finding is supported by TOE observations.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available