Journal
FOOD CHEMISTRY
Volume 233, Issue -, Pages 282-289Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2017.04.126
Keywords
Complex coacervation; Quercetin; Nanoencapsulation; Core-shell; Controlled release; Soft condensation; Nanoparticle
Funding
- Shiraz University [93GCU3M194065]
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Nature-made inherent transporting property of beta-lactoglobulin (BLG) was exploited to develop delivery systems for quercetin. After binding to BLG, quercetin was nanoencapsulated within soft-condensed nanostructures of BLG and sodium alginate (ALG). Fluorimetry results revealed that quercetin could bind to BLG even at acidic conditions. The amounts of stoichiometry binding (n) were 1.24 and 1.62 at pH values of 4 and 7, respectively. Formation of core-shell type nanostructures was confirmed by transmission electron microscopy. Quercetin was efficiently entrapped (>93%). The ejection from the carrier was very limited over time (<1% during 1 month). The protection of nanoencapsulated quercetin was at least 3 times better than that of free quercetin. Quercetin was not released (<3.5% during 6 h) in simulated gastric fluids (pH 1.2 and 4); while, a sustained release (77% during 12 h) was observed in simulated intestinal fluid (pH 7.4). (C) 2017 Elsevier Ltd. All rights reserved.
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