Journal
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
Volume 13, Issue -, Pages -Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1759720X211006979
Keywords
bone mineral density; bone turnover markers; cholecalciferol; epigenetics; Maternal Vitamin D Osteoporosis Study; osteoporosis; pregnancy
Categories
Funding
- Medical Research Council (UK)
- National Institute for Health Research
- Wellcome Trust
- versus Arthritis
- Royal Osteoporosis Society Osteoporosis and Bone Research Academy
- International Osteoporosis Foundation
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Research on the positive effects of prenatal vitamin D supplementation on offspring bone development and the underlying biological mechanisms, can inform clinical care and public health policies.
Optimisation of skeletal mineralisation in childhood is important to reduce childhood fracture and the long-term risk of osteoporosis and fracture in later life. One approach to achieving this is antenatal vitamin D supplementation. The Maternal Vitamin D Osteoporosis Study is a randomised placebo-controlled trial, the aim of which was to assess the effect of antenatal vitamin D supplementation (1000 IU/day cholecalciferol) on offspring bone mass at birth. The study has since extended the follow up into childhood and diversified to assess demographic, lifestyle and genetic factors that determine the biochemical response to antenatal vitamin D supplementation, and to understand the mechanisms underpinning the effects of vitamin D supplementation on offspring bone development, including epigenetics. The demonstration of positive effects of maternal pregnancy vitamin D supplementation on offspring bone development and the delineation of underlying biological mechanisms inform clinical care and future public-health policies.
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