Journal
POLYMER CHEMISTRY
Volume 12, Issue 17, Pages 2592-2597Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1py00106j
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Funding
- Natural Science Foundation of China [51533009, 22075326, 22071271, 21805317]
- Guangdong Innovative and Entrepreneurial Research Team Program [2013S086]
- Natural Science Foundation of Guangdong Province [2014A030312018]
- Fundamental Research Funds for the Central Universities [19lgpy16, 20lgpy03]
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The study presented a facile method for the synthesis of cationic polymers with controlled topological structures and tunable charge densities using thio-bromo click chemistry. Three types of polymeric precursors were prepared and modified to yield cationic polymers with potential for biomedical applications. Size exclusion chromatography (SEC) and H-1 NMR characterization confirmed the successful synthesis of these cationic polymers with controlled molecular weights and topological structures.
Synthesis of cationic polymers possessing significant therapeutic potential is of tremendous research interest. Here, we report a facile synthesis of poly(epsilon-caprolactone) (PCL) based cationic polymers with controlled topological structures and tunable charge densities via postpolymerization modification using thio-bromo click chemistry. Three types of polymeric precursors were prepared by ring-opening polymerization (ROP) or combination of ROP and azide-alkyne click reaction, including linear homopolymer poly(alpha-bromo-epsilon-caprolactone) (P(CL-Br)), block copolymer PCL-b-P(CL-Br), and bottlebrush polymer PCL-g-(PCL-b-P(CL-Br)), and then the P(CL-Br) blocks or segments were modified using the thio-bromo click reaction with a thiol bearing a tertiary amino group, yielding the corresponding cationic polymers, respectively. Size exclusion chromatography (SEC) and H-1 NMR characterization demonstrated successful synthesis of the cationic polymers with controlled molecular weights and topological structures that may have great potential for biomedical applications.
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