Journal
ANNALS OF THE AMERICAN THORACIC SOCIETY
Volume 18, Issue 4, Pages 668-677Publisher
AMER THORACIC SOC
DOI: 10.1513/AnnalsATS.202009-1161OC
Keywords
sleep apnea; obstructive; reduced expiratory pressure; sleep-disordered breathing; therapy
Categories
Funding
- U.S. National Institute for Occupational Safety and Health (NIOSH)/U.S. Centers for Disease Control and Prevention (CDC) [U01OH010415]
- U.S. National Institutes of Health (NIH) [HL109156]
- New York University Clinical and Translational Science Award [UL1 TR001445]
- National Center for Advancing Translational Sciences
- NIH-National Institutes of Environmental Health Sciences [P30 ES005022]
- CDC/NIOSH [U10 OH008232, 200-2011-39356, 200-2011-39385, 200-2011-39384]
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Contrary to expectations, the study results showed no significant difference in adherence to CPAP (FLEX) between subjects with high or low nasal resistance. Overall, CPAP demonstrated slightly better adherence compared to CPAP (FLEX).
Rationale: Continuous positive airway pressure (CPAP) adherence is often poor in obstructive sleep apnea (OSA) and may be influenced by nasal resistance. CPAP with a reduction of expiratory pressure (CPAP(FLEX)) may reduce discomfort in those with high nasal resistance and improve adherence in this subgroup. Objectives: To evaluate the association of positive airway pressure (PAP) treatment adherence to nasal resistance and examine if CPAP(FLEX) improves adherence over CPAP in subjects with high nasal resistance. Methods: A randomized double-blind crossover trial of 4 weeks each of CPAP(FLEX )versus CPAP in subjects exposed to World Trade Center dust with OSA stratified by nasal resistance, measured by 4-Phase Rhinomanometry. Results: Three hundred seventeen subjects with OSA (mean, apneahypopnea index with 4% O-2 desaturation for hypopnea = 17 +/- 14/h) were randomized. Overall, PAP adherence was poor, but adherence to CPAP (n = 239; mean hours per night [95% confidence interval (CI)]), 1.97 h (1.68 to 2.26) was greater than adherence to CPAP(FLEX) (n = 249; 1.65 h [1.39 to 1.91]; difference of 0.31 h [0.03; 0.6]; P < 0.05). Contrary to our hypothesis there was no correlation between nasal resistance and adherence to CPAP (r= 0.098; P = not significant) or CPAP(FLEX) (r = 0.056; P = not significant). There was no difference in adherence between CPAP and CPAP(FLEX) (mean Delta hours [95% CI]) in subjects with low resistance (0.33 h [ -0.10 to 0.76]) or high nasal resistance (0.26 h [ -0.14 to 0.66]). No significant differences were observed in any of the secondary outcomes between PAP modes. Conclusions: Contrary to expectations, our data do not show better adherence to CPAP(FLEX) than to CPAP in subjects with high or low nasal resistance and do show clinically insignificant better adherence overall with CPAP.
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