4.7 Review

The chemistry and biology of guanidine secondary metabolites

Journal

NATURAL PRODUCT REPORTS
Volume 38, Issue 3, Pages 586-667

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d0np00051e

Keywords

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Funding

  1. Brazilian funding agency FAPESP [2013/50228-8, 2016/21341-9, 2019/06359-7, 2019/01235-8, 2017/22164-6]
  2. CNPq [302197/2017-6]

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This review focuses on guanidine natural products isolated from microorganisms, marine invertebrates, terrestrial plants, amphibians, and spiders from 2017 to 2019. It covers topics such as the discovery of new metabolites, total synthesis of natural guanidine compounds, their biological activities and mechanisms of action, biosynthesis, and ecological functions.
Covering: 2017-2019 Guanidine natural products isolated from microorganisms, marine invertebrates and terrestrial plants, amphibians and spiders, represented by non-ribosomal peptides, guanidine-bearing polyketides, alkaloids, terpenoids and shikimic acid derived, are the subject of this review. The topics include the discovery of new metabolites, total synthesis of natural guanidine compounds, biological activity and mechanism-of-action, biosynthesis and ecological functions.

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