Journal
JOURNAL OF DIETARY SUPPLEMENTS
Volume 18, Issue 3, Pages 248-260Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/19390211.2020.1757798
Keywords
Hyperuricemia; serum urate; curcumin; turmeric; urine uric acid clearance
Categories
Funding
- Thai Rheumatism Association [F1/2561]
- Department of Medicine, Phramongkutklao Hospital
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The study found that curcumin was not superior to placebo in reducing serum urate and increasing urine uric acid clearance.
Background/objective: Hyperuricemia leads to gout and renal complications and may increase cardiovascular risk. Curcumin inhibits xanthine oxidase and increases uricosuric activity and, as a result, decreases serum urate (SU). This randomized controlled trial aimed to determine the effects of curcumin versus placebo on SU in subjects with asymptomatic hyperuricemia (SU level >= 6 mg/dL in women or >= 7 mg/dL in men). Methods: Thirty-nine subjects with persistent hyperuricemia were randomized to receive curcumin (500-mg capsules twice daily, 20 subjects) or placebo (19 subjects). Primary outcome was the difference between SU before and 8 weeks after randomization. Secondary outcomes were differences between urine uric acid (UUA) clearance, fasting plasma glucose (FPG), and lipid profiles before and 8 weeks after randomization and adverse events. Results: Out of 39 subjects, there were no differences at baseline SU, UUA clearance, FPG, lipid profiles, and demographics between curcumin and placebo groups. After 8 weeks, SU was significantly decreased in both groups (6.9% in curcumin group, p = 0.002, and 5.0% in placebo group, p = 0.009). However, there was no difference in SU reduction between the two groups (p = 0.532). There were no differences in UUA, FPG, lipid profiles, or adverse events in either group at 8 weeks after randomization. The most common adverse event was diarrhea with no treatment required. Conclusion: Curcumin was not superior to placebo in reducing serum urate and in increasing UUA clearance.
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