Journal
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
Volume 18, Issue 3, Pages 995-1002Publisher
IEEE COMPUTER SOC
DOI: 10.1109/TCBB.2019.2963867
Keywords
Radiomics; deep learning; vessel invasion; cervical cancer; MRI
Categories
Funding
- National Natural Science Foundation of China [61601450, 61871371, 81830056, 81872363]
- Science and Technology Planning Project of Guangdong Province [2017B020227012]
- Foundation for Key Program of Shenyang [17230907]
- Shenyang Municipal Science and Technology Project [F16206923]
- Research Fund for Science and Public Affairs of Liaoning Province [20170030]
- Natural Science Foundation Program of Liaoning Province [2019-ZD-1093]
- Climbing Fund of National Cancer Center [NCC201806B011]
- Support Program of Youth Science and Technology Innovation Talents of Shenyang City [RC180269]
- Supporting Fund for Big data in Health Care [HMB201903101]
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This study achieved excellent performance in differentiating vessel invasion from non-vessel invasion in cervical cancer using deep learning methods, surpassing existing radiomic methods in the field.
This article aims to build deep learning-based radiomic methods in differentiating vessel invasion from non-vessel invasion in cervical cancer with multi-parametric MRI data. A set of 1,070 dynamic T1 contrast-enhanced (DCE-T1) and 986 T2 weighted imaging (T2WI) MRI images from 167 early-stage cervical cancer patients (January 2014 - August 2018) were used to train and validate deep learning models. Predictive performances were evaluated using receiver operating characteristic (ROC) curve and confusion matrix analysis, with the DCE-T1 showing more discriminative results than T2WI MRI. By adopting an attention ensemble learning strategy that integrates both MRI sequences, the highest average area was obtained under the ROC curve (AUC) of 0.911 (Sensitivity = 0.881 and Specificity = 0.752). The superior performances in this article, when compared to existing radiomic methods, indicate that a wealth of deep learning-based radiomics could be developed to aid radiologists in preoperatively predicting vessel invasion in cervical cancer patients.
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