4.7 Review

Understanding T cell phenotype for the design of effective chimeric antigen receptor T cell therapies

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Cross-talk between tumors at anatomically distinct sites

Amanda J. Oliver et al.

Summary: Cancer tissue is heterogeneous and tumor microenvironment cells can communicate with each other to influence their function. Moreover, tumors located remotely from each other can engage in cross-talk that can influence their responsiveness to various therapies. Communication between cancer cells and immune cells can lead to immunosuppression.

FEBS JOURNAL (2021)

Article Oncology

Deletion of Cbl-b inhibits CD8+ T-cell exhaustion and promotes CAR T-cell function

Jitendra Kumar et al.

Summary: The study identified Cbl-b as a potential target for overcoming exhausted CAR T-cell function in solid tumors. Inhibition of Cbl-b restored effector function of exhausted T cells. Depletion of Cbl-b enhanced CAR T-cell efficacy in reducing tumor growth, decreasing exhausted T cells, and increasing effector cytokine expression.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Multidisciplinary Sciences

An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors

Katharina Reinhard et al.

SCIENCE (2020)

Review Medicine, Research & Experimental

State of the art in CAR T cell therapy for CD19+ B cell malignancies

Matthew J. Frigault et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Multidisciplinary Sciences

NR4A transcription factors limit CAR T cell function in solid tumours

Joyce Chen et al.

NATURE (2019)

Article Immunology

CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer

Laura M. McLane et al.

Annual Review of Immunology (2019)

Article Immunology

Single-cell transcriptomic analysis of tissue-resident memory T cells in human lung cancer

James Clarke et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

Article Multidisciplinary Sciences

TOX is a critical regulator of tumour-specific T cell differentiation

Andrew C. Scott et al.

NATURE (2019)

Article Multidisciplinary Sciences

TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion

Hyungseok Seo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Biochemistry & Molecular Biology

Glycoengineering of chimeric antigen receptor (CAR) T-cells to enforce E-selectin binding

Nandini Mondal et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Article Multidisciplinary Sciences

Enterotoxins can support CAR T cells against solid tumors

Bianca von Scheidt et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Multidisciplinary Sciences

CXCR1-or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors

Linchun Jin et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

Tumor-reprogrammed resident T cells resist radiation to control tumors

Ainhoa Arina et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

c-Jun overexpression in CAR T cells induces exhaustion resistance

Rachel C. Lynn et al.

NATURE (2019)

Article Immunology

Defining 'T cell exhaustion'

Christian U. Blank et al.

NATURE REVIEWS IMMUNOLOGY (2019)

Review Biochemistry & Molecular Biology

Selectins in cancer immunity

Lubor Borsig

GLYCOBIOLOGY (2018)

Review Biochemistry & Molecular Biology

Integrins in T Cell Physiology

Alessandra Bertoni et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Biochemistry & Molecular Biology

Distinct human (1,3)-fucosyltransferases drive Lewis-X/sialyl Lewis-X assembly in human cells

Nandini Mondal et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Biotechnology & Applied Microbiology

IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor

Keishi Adachi et al.

NATURE BIOTECHNOLOGY (2018)

Review Immunology

Tissue-resident memory T cells at the center of immunity to solid tumors

Derk Amsen et al.

NATURE IMMUNOLOGY (2018)

Article Multidisciplinary Sciences

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

Kristen E. Pauken et al.

SCIENCE (2016)

Article Immunology

The Transcription Factor NFAT Promotes Exhaustion of Activated CD8+ T Cells

Gustavo J. Martinez et al.

IMMUNITY (2015)

Article Multidisciplinary Sciences

Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy

Dongjun Peng et al.

NATURE (2015)

Article Biochemistry & Molecular Biology

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

Adrienne H. Long et al.

NATURE MEDICINE (2015)

Review Oncology

Trafficking of T Cells into Tumors

Clare Y. Slaney et al.

CANCER RESEARCH (2014)

Review Immunology

Memory T Cell Subsets, Migration Patterns, and Tissue Residence

Scott N. Mueller et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 31 (2013)

Review Immunology

Lineage relationship of effector and memory T cells

Nicholas P. Restifo et al.

CURRENT OPINION IN IMMUNOLOGY (2013)

Article Medicine, Research & Experimental

Superior T memory stem cell persistence supports long-lived T cell memory

Enrico Lugli et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Review Oncology

Gene-engineered T cells for cancer therapy

Michael H. Kershaw et al.

NATURE REVIEWS CANCER (2013)

Review Oncology

Paths to stemness: building the ultimate antitumour T cell

Luca Gattinoni et al.

NATURE REVIEWS CANCER (2012)

Review Oncology

CXCR3 in T cell function

Joanna R. Groom et al.

EXPERIMENTAL CELL RESEARCH (2011)

Article Medicine, Research & Experimental

IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells

Daniel T. Fisher et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Article Biochemistry & Molecular Biology

A human memory T cell subset with stem cell-like properties

Luca Gattinoni et al.

NATURE MEDICINE (2011)

Review Immunology

Cross-priming in health and disease

Christian Kurts et al.

NATURE REVIEWS IMMUNOLOGY (2010)

Article Biochemistry & Molecular Biology

Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

Luca Gattinoni et al.

NATURE MEDICINE (2009)

Article Immunology

The precursors of memory: models and controversies

Rafi Ahmed et al.

NATURE REVIEWS IMMUNOLOGY (2009)

Article Hematology

CD43 is a ligand for E-selectin on CLA+ human T cells

RC Fuhlbrigge et al.

BLOOD (2006)

Article Biochemistry & Molecular Biology

Host-reactive CD8+ memory stem cells in graft-versus-host disease

Y Zhang et al.

NATURE MEDICINE (2005)

Article Multidisciplinary Sciences

Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells

CA Klebanoff et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Medicine, Research & Experimental

Progressive loss of endothelial P-selectin expression with increasing malignancy in colorectal cancer

CFJM Peeters et al.

LABORATORY INVESTIGATION (2005)

Article Immunology

Lineage relationship and protective immunity of memory CD8 T cell subsets

EJ Wherry et al.

NATURE IMMUNOLOGY (2003)

Review Biochemistry & Molecular Biology

Fucosyltransferases: structure/function studies

T de Vries et al.

GLYCOBIOLOGY (2001)