4.7 Article

A mitochondria-targeted near-infrared fluorescent probe for imaging viscosity in living cells and a diabetic mice model

Journal

CHEMICAL COMMUNICATIONS
Volume 57, Issue 36, Pages 4376-4379

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc01104a

Keywords

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Funding

  1. National Natural Science Foundation of China [21705120]
  2. Project of Shandong Province Higher Educational Outstanding Youth Innovation Team [2019KJM008]
  3. Natural Science Foundation of Shandong Province, China [ZR2017LB016]
  4. Project of Shandong Province Higher Educational Science and Technology Program [J17KB074]

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A mitochondria-targeted fluorescent probe NIR-V with 700 nm emission was designed to monitor cell viscosity changes with high selectivity and sensitivity, which was applied to detect intracellular viscosity and image pancreatic tissue in a diabetic mouse model. Probe NIR-V provides an effective way to diagnose viscosity related diseases.
A mitochondria-targeted near-infrared fluorescent probe NIR-V with 700 nm emission was designed to monitor cell viscosity changes with high selectivity and sensitivity, which was applied to detect the intracellular viscosity and image pancreatic tissue in a diabetic mouse model. Probe NIR-V provides an effective way to diagnose viscosity related diseases.

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