Self-cyclization vs. dimerization of o-alkenyl arylisocyanides: chemodivergent synthesis of quinolines and pyrrolo-fused diindoles

Solvent-dependent chemoselective Morita-Baylis-Hillman-type self-cyclization and dimerization of o-alkenyl arylisocyanides were developed. These chemodivergent reactions provide concise access to the efficient synthesis of various 3-acylquinoline and pyrrolo[1,2-a:3,4-b ']diindole frameworks via the distinct domino process from the same starting materials.

Automated summary

A new method for solvent-dependent chemoselective Morita-Baylis-Hillman-type self-cyclization and dimerization of o-alkenyl arylisocyanides was developed, providing concise access to various 3-acylquinoline and pyrrolo[1,2-a:3,4-b ']diindole frameworks via distinct domino processes from the same starting materials.