4.4 Review

Overcoming the Tumor Microenvironmental Barriers of Pancreatic Ductal Adenocarcinomas for Achieving Better Treatment Outcomes

Related references

Note: Only part of the references are listed.
Article Oncology

Inhibition of Hedgehog Signaling Alters Fibroblast Composition in Pancreatic Cancer

Nina G. Steele et al.

Summary: The study reveals that Hedgehog signaling is uniquely activated in fibroblasts in PDAC, with varying levels of elevation in myofibroblastic CAFs compared to inflammatory CAFs. Inhibition of the Hedgehog pathway slows tumor growth, alters the composition of CAF subtypes, and impacts immune cell infiltration, leading to increased immunosuppression.

CLINICAL CANCER RESEARCH (2021)

Article Oncology

A MET Targeting Antibody-Drug Conjugate Overcomes Gemcitabine Resistance in Pancreatic Cancer

Alex Cazes et al.

Summary: Pancreatic cancer is an aggressive disease with a poor prognosis, mainly treated with chemotherapy. The newly developed TR1801-ADC has shown promising results in inducing specific cytotoxicity in pancreatic cancer cells, inhibiting tumor growth, and demonstrating synergy with gemcitabine in vitro and in vivo. These findings suggest a novel therapeutic approach for the treatment of pancreatic cancer.

CLINICAL CANCER RESEARCH (2021)

Article Pathology

mAb Das-1 identifies pancreatic ductal adenocarcinoma and high-grade pancreatic intraepithelial neoplasia with high accuracy

Koushik K. Das et al.

Summary: mAb Das-1 shows high specificity in distinguishing high-grade PanIN/PDAC from low-grade PanIN lesions, which may be helpful for pre-operative diagnosis and clinical risk stratification of PDAC.

HUMAN PATHOLOGY (2021)

Review Pharmacology & Pharmacy

Improving the therapeutic efficiency of noncoding RNAs in cancers using targeted drug delivery systems

Rami Alzhrani et al.

DRUG DISCOVERY TODAY (2020)

Article Oncology

Cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

Review Pharmacology & Pharmacy

Cancer stem cells as therapeutic targets of pancreatic cancer

Ebrahim Razi et al.

FUNDAMENTAL & CLINICAL PHARMACOLOGY (2020)

Article Gastroenterology & Hepatology

Pancreatic stellate cells: Aiding and abetting pancreatic cancer progression

Srinivasa P. Pothula et al.

PANCREATOLOGY (2020)

Review Oncology

The tumour microenvironment in pancreatic cancer - clinical challenges and opportunities

Won Jin Ho et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

Review Biochemistry & Molecular Biology

The Resistance Mechanisms of Checkpoint Inhibitors in Solid Tumors

Evangelos Koustas et al.

BIOMOLECULES (2020)

Review Oncology

Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma

Aaron J. Grossberg et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

Review Oncology

Hypoxia and pancreatic ductal adenocarcinoma

Akio Yamasaki et al.

CANCER LETTERS (2020)

Review Oncology

Immunotherapy for pancreatic cancer: A 2020 update

Dimitrios Schizas et al.

CANCER TREATMENT REVIEWS (2020)

Review Biochemistry & Molecular Biology

Mechanically stressed cancer microenvironment: Role in pancreatic cancer progression

Matthew Hadden et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2020)

Review Biochemistry & Molecular Biology

Small molecule inhibitors in pancreatic cancer

Jufeng Sun et al.

RSC MEDICINAL CHEMISTRY (2020)

Review Oncology

Updates in pancreatic cancer: Modest gains and hopeful targets

Amber Draper

JOURNAL OF ONCOLOGY PHARMACY PRACTICE (2019)

Review Cell Biology

Deciphering role of FGFR signalling pathway in pancreatic cancer

Xiaodiao Kang et al.

CELL PROLIFERATION (2019)

Review Biotechnology & Applied Microbiology

Nanomedicine for Imaging and Therapy of Pancreatic Adenocarcinoma

Giulia Brachi et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2019)

Editorial Material Oncology

The Next Wave of Stroma-Targeting Therapy in Pancreatic Cancer

Huocong Huang et al.

CANCER RESEARCH (2019)

Article Gastroenterology & Hepatology

Combating pancreatic cancer with PI3K pathway inhibitors in the era of personalised medicine

James R. W. Conway et al.

Article Audiology & Speech-Language Pathology

Feasibility of Acupuncture to Induce Sleep for Brainstem Auditory Evoked Response Testing

Nicole Holmer et al.

AMERICAN JOURNAL OF AUDIOLOGY (2019)

Meeting Abstract Oncology

Gemcitabine primes the pancreatic tumor microenvironment for second-line immunotherapy

Daniel R. Principe et al.

CANCER RESEARCH (2019)

Review Oncology

Targeting Hypoxia to Improve Non-Small Cell Lung Cancer Outcome

Ahmed Salem et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)

Review Oncology

Targeting Hypoxia to Improve Non-Small Cell Lung Cancer Outcome

Ahmed Salem et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)

Review Oncology

The biology and role of CD44 in cancer progression: therapeutic implications

Chen Chen et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

Article Biochemistry & Molecular Biology

MicroRNA-494 promotes cancer progression and targets adenomatous polyposis coli in colorectal cancer

Ying Zhang et al.

MOLECULAR CANCER (2018)

Article Nanoscience & Nanotechnology

CD44 directed nanomicellar payload delivery platform for selective anticancer effect and tumor specific imaging of triple negative breast cancer

Zhaoxian Wang et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2018)

Review Gastroenterology & Hepatology

Immune therapies in pancreatic ductal adenocarcinoma: Where are we now?

Marc Hilmi et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2018)

Article Oncology

NRG1 Fusions in KRAS Wild-Type Pancreatic Cancer

Christoph Heining et al.

CANCER DISCOVERY (2018)

Review Oncology

Role of Gene Therapy in Pancreatic Cancer-A Review

Mizuho Sato-Dahlman et al.

CANCERS (2018)

Article Gastroenterology & Hepatology

Stratification of Pancreatic Ductal Adenocarcinomas Based on Tumor and Microenvironment Features

Francesco Puleo et al.

GASTROENTEROLOGY (2018)

Review Biochemistry & Molecular Biology

Emerging Role of Immune Checkpoint Blockade in Pancreatic Cancer

Shravanti Macherla et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Multidisciplinary Sciences

ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling

Andreia V. Pinho et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors

Sophie Escot et al.

NATURE COMMUNICATIONS (2018)

Review Oncology

Immunotherapy and pancreatic cancer: unique challenges and potential opportunities

Kate Young et al.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2018)

Review Biochemistry & Molecular Biology

Pancreatic Ductal Adenocarcinoma: Current and Evolving Therapies

Aleksandra Adamska et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Nanoscience & Nanotechnology

Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac

Thangirala Sudha et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

Review Cell Biology

Targeting stroma in pancreatic cancer: Promises and failures of targeted therapies

Afsane Bahrami et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2017)

Review Oncology

DNA Repair Dysfunction in Pancreatic Cancer: A Clinically Relevant Subtype for Drug Development

Talia Golan et al.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2017)

Article Multidisciplinary Sciences

Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

Vinod P. Balachandran et al.

NATURE (2017)

Letter Medicine, General & Internal

T-Cell Transfer Therapy Targeting Mutant KRAS

Asaf Maoz et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Review Medicine, General & Internal

The TGF-β/Smad4 Signaling Pathway in Pancreatic Carcinogenesis and Its Clinical Significance

Sunjida Ahmed et al.

JOURNAL OF CLINICAL MEDICINE (2017)

Review Biochemistry & Molecular Biology

Targeting the Akt/PI3K Signaling Pathway as a Potential Therapeutic Strategy for the Treatment of Pancreatic Cancer

Safieh Ebrahimi et al.

CURRENT MEDICINAL CHEMISTRY (2017)

Article Oncology

The Pancreatic Cancer Microenvironment

Stephanie K. Dougan

CANCER JOURNAL (2017)

Review Biochemistry & Molecular Biology

Cancer-associated fibroblasts modulate growth factor signaling and extracellular matrix remodeling to regulate tumor metastasis

Begum Erdogan et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2017)

Review Oncology

Targeting neoantigens to augment antitumour immunity

Mark Yarchoan et al.

NATURE REVIEWS CANCER (2017)

Review Medicine, Research & Experimental

Nanotechnology for delivery of gemcitabine to treat pancreatic cancer

Gebremariam Birhanu et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

Review Pharmacology & Pharmacy

Molecular signature of pancreatic adenocarcinoma: an insight from genotype to phenotype and challenges for targeted therapy

Ibrahim H. Sahin et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2016)

Review Oncology

Combination cancer immunotherapies tailored to the tumour microenvironment

Mark J. Smyth et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2016)

Review Medicine, General & Internal

Role of immune cells in pancreatic cancer from bench to clinical application An updated review

Jae Hyuck Chang et al.

MEDICINE (2016)

Review Biochemistry & Molecular Biology

Cancer stem cell metabolism: a potential target for cancer therapy

Abhijeet Deshmukh et al.

MOLECULAR CANCER (2016)

Meeting Abstract Nanoscience & Nanotechnology

Smart targeted therapy by self-assembled supramolecular nanosystems

Kazunori Kataoka

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2016)

Review Oncology

Nanomedicine strategies to overcome the pathophysiological barriers of pancreatic cancer

Pavan P. Adiseshaiah et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2016)

Review Pharmacology & Pharmacy

Targeting tumor tolerance: A new hope for pancreatic cancer therapy?

Daniel Delitto et al.

PHARMACOLOGY & THERAPEUTICS (2016)

Article Gastroenterology & Hepatology

Management of pancreatic cancer in the elderly

Oliver Higuera et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2016)

Review Oncology

Cancer of the Pancreas: Molecular Pathways and Current Advancement in Treatment

Kishore Polireddy et al.

JOURNAL OF CANCER (2016)

Article Medicine, General & Internal

Pancreatic cancer

Jorg Kleeff et al.

NATURE REVIEWS DISEASE PRIMERS (2016)

Meeting Abstract Oncology

Phase II study of modified FOLFIRINOX for chemotherapy-naive patients with metastatic pancreatic cancer

Makoto Ueno et al.

JOURNAL OF CLINICAL ONCOLOGY (2016)

Article Nanoscience & Nanotechnology

An in vitro and in vivo study of gemcitabine-loaded albumin nanoparticles in a pancreatic cancer cell line

Xinzhe Yu et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2015)

Article Multidisciplinary Sciences

K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif

Frederick D. Tsai et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Biochemistry & Molecular Biology

Pancreatic tumor cell metabolism: Focus on glycolysis and its connected metabolic pathways

Fabienne Guillaumond et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2014)

Review Immunology

Single-cell technologies for monitoring immune systems

Pratip K. Chattopadhyay et al.

NATURE IMMUNOLOGY (2014)

Review Biotechnology & Applied Microbiology

Drugging the undruggable RAS: Mission Possible?

Adrienne D. Cox et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

Review Biochemistry & Molecular Biology

KRAS: feeding pancreatic cancer proliferation

Kirsten L. Bryant et al.

TRENDS IN BIOCHEMICAL SCIENCES (2014)

Review Biotechnology & Applied Microbiology

Pancreatic cancer: Role of the immune system in cancer progression and vaccine-based immunotherapy

Amedeo Amedei et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2014)

Article Biochemistry & Molecular Biology

Targeting gemcitabine containing liposomes to CD44 expressing pancreatic adenocarcinoma cells causes an increase in the antitumoral activity

Elisa Dalla Pozza et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2013)

Review Immunology

Inflammatory networks and immune surveillance of pancreatic carcinoma

Robert H. Vonderheide et al.

CURRENT OPINION IN IMMUNOLOGY (2013)

Article Pharmacology & Pharmacy

Identification and Usage of Fluorescent Probes as Nanoparticle Contrast Agents in Detecting Cancer

Manikanta Swamy Murahari et al.

CURRENT PHARMACEUTICAL DESIGN (2013)

Article Medicine, General & Internal

Adjuvant Chemotherapy With Gemcitabine and Long-term Outcomes Among Patients With Resected Pancreatic Cancer The CONKO-001 Randomized Trial

Helmut Oettle et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2013)

Article Nanoscience & Nanotechnology

Sensitization of pancreatic cancer cells to radiation by cerium oxide nanoparticle-induced ROS production

Melissa S. Wason et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2013)

Article Gastroenterology & Hepatology

Modified FOLFIRINOX Regimen With Improved Safety and Maintained Efficacy in Pancreatic Adenocarcinoma

Hemchandra Mahaseth et al.

PANCREAS (2013)

Article Multidisciplinary Sciences

Mutant KRAS is a druggable target for pancreatic cancer

Elina Zorde Khvalevsky et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Gastroenterology & Hepatology

The angiotensin II type I receptor blocker olmesartan inhibits the growth of pancreatic cancer by targeting stellate cell activities in mice

Atsushi Masamune et al.

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2013)

Review Physiology

Immune infiltrates as predictive markers of survival in pancreatic cancer patients

Maria Pia Protti et al.

FRONTIERS IN PHYSIOLOGY (2013)

Article Oncology

The incidence of pancreatic cancer in BRCA1 and BRCA2 mutation carriers

J. Iqbal et al.

BRITISH JOURNAL OF CANCER (2012)

Article Biochemistry & Molecular Biology

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

Haoqiang Ying et al.

Article Oncology

The Pancreas Cancer Microenvironment

Christine Feig et al.

CLINICAL CANCER RESEARCH (2012)

Article Gastroenterology & Hepatology

Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia

Mitsuro Kanda et al.

GASTROENTEROLOGY (2012)

Article Gastroenterology & Hepatology

StellaTUM: current consensus and discussion on pancreatic stellate cell research

Mert Erkan et al.

Article Immunology

Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma

Natalie Cook et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2012)

Review Gastroenterology & Hepatology

The role of stroma in pancreatic cancer: diagnostic and therapeutic implications

Mert Erkan et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2012)

Article Gastroenterology & Hepatology

c-Met Is a Marker of Pancreatic Cancer Stem Cells and Therapeutic Target

Chenwei Li et al.

GASTROENTEROLOGY (2011)

Article Nanoscience & Nanotechnology

Squalenoyl gemcitabine nanomedicine overcomes the low efficacy of gemcitabine therapy in pancreatic cancer

Soukaina Rejiba et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2011)

Article Medicine, General & Internal

FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Article Biochemistry & Molecular Biology

TP53INP1 decreases pancreatic cancer cell migration by regulating SPARC expression

M. Seux et al.

ONCOGENE (2011)

Article Oncology

c-MET as a potential therapeutic target and biomarker in cancer

J. Rafael Sierra et al.

Therapeutic Advances in Medical Oncology (2011)

Review Chemistry, Multidisciplinary

Cyclopamine and Hedgehog Signaling: Chemistry, Biology, Medical Perspectives

Philipp Heretsch et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)

Article Oncology

Hypoxia and Hypoxia-Inducible Factors: Master Regulators of Metastasis

Xin Lu et al.

CLINICAL CANCER RESEARCH (2010)

Article Biotechnology & Applied Microbiology

Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models

Mallika Singh et al.

NATURE BIOTECHNOLOGY (2010)

Review Pharmacology & Pharmacy

Targeted Delivery Systems for Oligonucleotide Therapeutics

Bo Yu et al.

AAPS JOURNAL (2009)

Article Chemistry, Multidisciplinary

Preparation of albumin nanospheres loaded with gemcitabine and their cytotoxicity against BXPC-3 cells in vitro

Jin-ming Li et al.

ACTA PHARMACOLOGICA SINICA (2009)

Article Cell Biology

HIF at a glance

M. Christiane Brahimi-Horn et al.

JOURNAL OF CELL SCIENCE (2009)

Article Multidisciplinary Sciences

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

Hua Tian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Oncology

Cancer-associated stroma fibroblasts promote pancreatic tumor progression

Rosa F. Hwang et al.

CANCER RESEARCH (2008)

Article Biochemistry & Molecular Biology

The epithelial-mesenchymal transition generates cells with properties of stem cells

Sendurai A. Mani et al.

Article Oncology

Sonic Hedgehog Promotes Desmoplasia in Pancreatic Cancer

Jennifer M. Bailey et al.

CLINICAL CANCER RESEARCH (2008)

Editorial Material Cell Biology

The use of GEM models for experimental cancer therapeutics

Aarthi Gopinathan et al.

DISEASE MODELS & MECHANISMS (2008)

Article Multidisciplinary Sciences

A paracrine requirement for hedgehog signalling in cancer

Robert L. Yauch et al.

NATURE (2008)

Article Oncology

Development and characterization of gemcitabine-resistant pancreatic tumor cells

Ami N. Shah et al.

ANNALS OF SURGICAL ONCOLOGY (2007)

Article Oncology

Identification of pancreatic cancer stem cells

Chenwei Li et al.

CANCER RESEARCH (2007)

Article Oncology

Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma

Jeffrey R. Infante et al.

JOURNAL OF CLINICAL ONCOLOGY (2007)

Article Multidisciplinary Sciences

A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

Catherine A. O'Brien et al.

NATURE (2007)

Review Oncology

Tumor-stroma interactions in pancreatic ductal adenocarcinoma

Daruka Mahadevan et al.

MOLECULAR CANCER THERAPEUTICS (2007)

Review Oncology

Drug penetration in solid tumours

Andrew I. Minchinton et al.

NATURE REVIEWS CANCER (2006)

Review Multidisciplinary Sciences

Hypoxia signalling in cancer and approaches to enforce tumour regression

Jacques Pouyssegur et al.

NATURE (2006)

Review Biochemistry & Molecular Biology

Cancer therapy: can the challenge be MET?

S Corso et al.

TRENDS IN MOLECULAR MEDICINE (2005)

Article Multidisciplinary Sciences

Identification of human brain tumour initiating cells

SK Singh et al.

NATURE (2004)

Article Oncology

Type I collagen promotes the malignant phenotype of pancreatic ductal adenocarcinoma

T Armstrong et al.

CLINICAL CANCER RESEARCH (2004)

Review Oncology

Exploiting tumour hypoxia in cancer treatment

JM Brown et al.

NATURE REVIEWS CANCER (2004)

Review Oncology

Adjuvant therapy in pancreatic cancer:: historical and current perspectives

JP Neoptolemos et al.

ANNALS OF ONCOLOGY (2003)

Article Multidisciplinary Sciences

Prospective identification of tumorigenic breast cancer cells

M Al-Hajj et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Review Multidisciplinary Sciences

Stem cells, cancer, and cancer stem cells

T Reya et al.

NATURE (2001)

Article Cell Biology

Identification of mediators stimulating proliferation and matrix synthesis of rat pancreatic stellate cells

E Schneider et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2001)

Article Oncology

Pancreatic tumors show high levels of hypoxia

AC Koong et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2000)