New Developments and Insights in the Improvement of Mycobacterium tuberculosis Vaccines and Diagnostics Within the End TB Strategy

Purpose of review The alignment of sustainable development goals (SDGs) with the End Tuberculosis (TB) strategy provides an integrated roadmap to implement key approaches towards TB elimination. This review summarizes current social challenges for TB control, and yet, recent developments in TB diagnosis and vaccines in the context of the End TB strategy and SDGs to transform global health. Recent findings Advances in non-sputum based TB biomarkers and whole genome sequencing technologies could revolutionize TB diagnostics. Moreover, synergistic novel technologies such as mRNA vaccination, nanovaccines and promising TB vaccine models are key promising developments for TB prevention and control. The End TB strategy depends on novel developments in point-of-care TB diagnostics and effective vaccines. However, despite outstanding technological developments in these fields, TB elimination will be unlikely achieved if TB social determinants are not fully addressed. Indeed, the End TB strategy and SDGs emphasize the importance of implementing sustainable universal health coverage and social protection.

Automated summary

The alignment of sustainable development goals with the End Tuberculosis strategy provides an integrated roadmap for TB elimination. Recent advancements in TB diagnosis and vaccines, including non-sputum based TB biomarkers, whole genome sequencing technologies, mRNA vaccination, nanovaccines, and promising TB vaccine models, offer promising developments for TB prevention and control in the context of global health transformation. However, addressing TB social determinants and implementing sustainable universal health coverage and social protection are essential for achieving TB elimination as emphasized by the End TB strategy and SDGs.