4.6 Article

Low awareness of past SARS-CoV-2 infection in healthy plasma donors

Journal

CELL REPORTS MEDICINE
Volume 2, Issue 3, Pages -

Publisher

CELL PRESS
DOI: 10.1016/j.xcrm.2021.100222

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Funding

  1. Sanquin Blood Supply Foundation
  2. Dutch Ministry of Health, Welfare and Sport

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The study found that 48% of individuals with antibodies did not suspect they had COVID-19, 11% reported no symptoms, and around 27% had only mild symptoms during the peak of the epidemic. Anosmia/ageusia and fever were found to be most strongly associated with seropositivity.
Awareness of infection with SARS-CoV-2 is crucial for the effectiveness of COVID-19 control measures. Here, we investigate awareness of infection and symptoms in relation to antibodies against SARS-CoV-2 in healthy plasma donors. We asked individuals donating plasma across the Netherlands between May 11th and 18th 2020 to report COVID-19-related symptoms, and we tested for antibodies indicative of a past infection with SARS-CoV-2. Among 3,676 with antibodies, and from questionnaire data, 239 (6.5%) are positive for SARS-CoV-2 antibodies. Of those, 48% suspect no COVID-19, despite the majority reporting symptoms; 11% of seropositive individuals report no symptoms and 27% very mild symptoms at any time during the first peak of the epidemic. Anosmia/ageusia and fever are most strongly associated with seropositivity. Almost half of seropositive individuals do not suspect SARS-CoV-2 infection. Improved recognition of COVID-19 symptoms, in particular, anosmia/ageusia and fever, is needed to reduce widespread SARS-CoV-2 transmission.

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