Journal
FOOD SCIENCE AND TECHNOLOGY RESEARCH
Volume 27, Issue 2, Pages 281-292Publisher
JAPANESE SOC FOOD SCI & TECHNOLOGY
DOI: 10.3136/fstr.27.281
Keywords
Citrus junos; yuzu peel extract; chloretone; fatty liver; hepatic steatosis; non-alcoholic fatty liver disease
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The study found that citrus yuzu peel ethanol extract can inhibit chloretone-induced fatty liver, and increasing the dosage of the fat-soluble fraction significantly improves fatty liver, with amphiphilic components playing a key role in the improvement.
This study investigated how citrus yuzu peel ethanol extract (YPE) affected both fatty liver and liver damage in rats fed with chloretone. Chloretone, a xenobiotic, was used to increase the amount of liver triacylglycerol and simultaneously elevate the concentration of serum alanine aminotransferase by which one can estimate the degree of liver damage. Both the water-soluble and fat-soluble fractions of YPE inhibited fatty liver caused by chloretone. Although the fat-soluble fraction had a lesser effect on fatty liver than the water-soluble fraction, increasing the dosage of the fat-soluble fraction significantly ameliorated fatty liver. Amphiphilic components in the fat-soluble fraction played a key role in improvement. Metabolomic analysis suggested that YPE components would suppress fatty acid synthesis and promote fatty acid degradation. The present study revealed that both the water-soluble and amphiphilic fractions of YPE have a novel inhibitory effect on fatty liver.
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