Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 42, Pages 5215-5218Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc01565f
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Funding
- National Natural Science Foundation of China [21625203, 21871126]
- Talent Induction Program for Youth Innovation Teams in Colleges and Universities of Shandong Province
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This new method involves a copper-catalyzed two-component amino-benzoyloxylation of unactivated alkenes using O-benzoylhydroxylamines as benzoyloxy sources. The chemoselectivity of the reaction depends on the position of the tethered olefins, providing a way for external-oxidant-free alkene difunctionalization. It directly utilizes O-benzoylhydroxylamines as benzoyloxy radical precursors and internal oxidants for synthesizing cyclic nitrones and isoxazolines.
A new copper-catalyzed two-component amino-benzoyloxylation of unactivated alkenes of unsaturated ketoximes with O-benzoylhydroxylamines as the benzoyloxy sources is developed. Chemoselectivity of this method toward amino-benzoyloxylation or oxy-benzoyloxylation of alkenyl ketoximes relies on the position of the tethered olefins, and provides an external-oxidant-free alkene difunctionalization route that directly utilizes O-benzoylhydroxylamines as the benzoyloxy radical precursors and internal oxidants for the divergent synthesis of cyclic nitrones and isoxazolines.
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