Journal
CHEMICAL PAPERS
Volume 75, Issue 8, Pages 3979-3987Publisher
SPRINGER INTERNATIONAL PUBLISHING AG
DOI: 10.1007/s11696-021-01631-w
Keywords
Bacterial cellulose nanofibers; Poly vinyl alcohol; Wound dressing; Antibiotic delivery
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Funding
- Scientific Projects Coordination Unit of Hitit University [MUH19002.16.001]
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The BC/PVA wound dressings loaded with antibiotics prepared via freeze-thawing exhibited high swelling ratio, low water loss percentage, and slow antibiotic release properties. They showed great antibacterial activity against E.coli and S. aureus, indicating their potential as wound dressings.
The current work was aimed to prepare bacterial cellulose/poly vinyl alcohol (BC/PVA) wound dressings loaded with antibiotic which were prepared via freeze-thawing. The swelling ratio of BC/PVA hydrogels was in the range of 188-240%. The water loss percentage of BC was improved with the addition of PVA. 30% of the cumulative ampicillin delivery from BC/PVA hydrogels was achieved during 120 h suggesting significant role of PVA incorporation since 50% of ampicillin was released from BC after 24 h. BC/PVA hydrogels showed great antibacterial activity against E.coli and S. aureus. The results revealed that BC/PVA hydrogels presented great potential as wound dressings with high swelling ratio, low water loss percentage and slow antibiotic release properties.
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