Journal
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
Volume 32, Issue 2, Pages 229-235Publisher
OXFORD UNIV PRESS
DOI: 10.1093/icvts/ivaa264
Keywords
Coronary artery bypass grafting; Aortic valve replacement; Neurological injury; Biomarkers
Funding
- Danish Heart Foundation [24R97-A5179-22868, 15-R99-A6034-22905]
- Research Foundations at Rigshospitalet [E-22329-01]
- University of Copenhagen, Denmark
- Lundbeck Foundation [R186-20152132]
- Swedish Research Council [2017-00915, 201802532]
- Alzheimer Drug Discovery Foundation (ADDF), USA [201809-2016615, 201809-2016862]
- European Research Council [681712]
- Swedish Alzheimer Foundation [AF742881]
- Hjarnfonden, Sweden [FO2017-0243]
- Swedish government [ALFGBG-715986, ALFGBG-720931]
- Swedish County Councils
- the ALF-agreement [ALFGBG-715986, ALFGBG-720931]
- NovoNordisk Foundation [NNF17OC0028706]
- MRC [UKDRI-1003] Funding Source: UKRI
Ask authors/readers for more resources
This study found no significant differences in levels of biomarkers of neurological injury in patients undergoing elective or subacute CABG and/or aortic valve replacement randomized to either a target MAP of 40-50 mmHg or a target MAP of 70-80 mmHg during CBP.
OBJECTIVES: Cardiac surgery is associated with risk of cerebral injury and mean arterial pressure (MAP) during cardiopulmonary bypass (CPB) is suggested to be associated with cerebral injury. The `Perfusion Pressure Cerebral Infarcts' (PPCI) trial randomized patients undergoing coronary artery bypass grafting (CABG) and/or aortic valve replacement to a MAP of 40-50 or 70-80 mmHg during CPB and found no difference in clinical or imaging outcomes between the groups. We here present PPCI trial predefined secondary end points, consisting of biomarkers of brain injury. METHODS: Blood was collected from PPCI trial patients at baseline, 24 and 48 h after induction of anaesthesia and at discharge from the surgical ward. Blood was analysed for neuron-specific enolase, tau, neurofilament light and the glial marker glial fibrillary acidic protein. Linear mixed models were used to analyse differences in biomarker value changes from baseline between the 2 MAP allocation groups. RESULTS: A total of 193 (98%) patients were included. We found no differences in biomarker levels over time from baseline to discharge between the 2 MAP allocation groups (P-NSE = 0.14, P-Tau = 0.46, P-NFL = 0.21, P-GFAP = 0.13) and the result did not change after adjustment for age, sex and type of surgery. CONCLUSIONS: We found no significant differences in levels of biomarkers of neurological injury in patients undergoing elective or subacute CABG and/or aortic valve replacement randomized to either a target MAP of 40-50 mmHg or a target MAP of 70-80 mmHg during CBP.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available