Journal
AGEING RESEARCH REVIEWS
Volume 22, Issue -, Pages 20-38Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2015.04.004
Keywords
Brain calcification; Fahr's disease; Hypoparathyroidism; Genetics; Molecular biology
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Funding
- National Natural Science Foundation of China [81271921, 81441033, 81101339]
- Sheng Hua Scholars Program of Central South University, China
- Research Fund for the Doctoral Program of Higher Education of China [20110162110026]
- Natural Science Foundation of Hunan Province, China [10JJ5029, 2015JJ4088]
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Brain calcification is a common neuroimaging finding in patients with neurological, metabolic, or developmental disorders, mitochondrial diseases, infectious diseases, traumatic or toxic history, as well as in otherwise normal older people. Patients with brain calcification may exhibit movement disorders, seizures, cognitive impairment, and a variety of other neurologic and psychiatric symptoms. Brain calcification may also present as a single, isolated neuroimaging finding. When no specific cause is evident, a genetic etiology should be considered. The aim of the review is to highlight clinical disorders associated with brain calcification and provide summary of current knowledge of diagnosis, genetics, and pathogenesis of brain calcification. (C) 2015 Elsevier B.V. All rights reserved.
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