Ellagic acid protects against LPS-induced acute lung injury through inhibition of nuclear factor kappa B, proinflammatory cytokines and enhancement of interleukin-10

Ellagic acid is a naturally occurring polyphenolic compound which is found in many fruits, nut galls and plant extracts. In the present study, we explored the ability of ellagic acid to modulate lipopolysaccharides (LPS) response using macrophage-mediated inflammatory conditions and acute lung injury (ALI). The data showed that ellagic acid reduced TNF-alpha, IL-6 and IL-1 beta secretions, enhance IL-10 production by LPS-stimulated RAW 264.7 macrophages in vitro. In murine ALI model, mice were treated with ellagic acid prior to LPS challenge. The data showed that ellagic acid possess a protective effect on LPS-induced ALI in mice. The underlying mechanism may be through shocking the NF-kappa B pathway to attenuate the nonspecific pulmonary inflammation induced by LPS administration.