Practical allylation with unactivated allylic alcohols under mild conditions

A practical palladium/calcium catalytic system was developed for dehydrative allylation with unactivated allylic alcohols. EtOH solvent with a H2O additive was identified as powerful medium to accelerate proton transfer. This catalytic system and environmentally benign medium enabled a variety of soft carbonic nucleophiles and allylic alcohols to react smoothly at room temperature with water as the only byproduct. A wide spectrum of allylic compounds bearing a variety of functional groups can be obtained with high to excellent yields.

Automated summary

A practical palladium/calcium catalytic system was developed for dehydrative allylation with unactivated allylic alcohols, utilizing ethanol solvent with a water additive to accelerate proton transfer. This system allowed for smooth reactions at room temperature, producing allylic compounds with a variety of functional groups in high to excellent yields.