Anticancer and antibacterial activity of green synthesized silver nanoparticles using Adina cordifolia

Extracts from plants are put to use for the green production of nanoparticles, since they possess compounds which have the potential metal reducing ability, biologically active and environment-friendly, in abundance. The present study investigates the production of silver nanoparticles (AgNPs) via the process of reducing silver nitrate by the cell-free leaf and stem aqueous extracts of Adina cordifolia (A. cordifolia) and its potential anticancer and antibacterial doings. The UV?Visible, FT-IR, XRD and SEM confirmed the synthesis of smaller, uniformly spherical AgNPs (10?45 nm) from silver nitrate upon incubation with leaf and stem extract of A. cordifolia. The A. cordifolia stem extract synthesized AgNPs have shown noteworthy anticancer commotion against human breast and prostate adenocarcinoma (MDAMB-231 and PC-3) cells with the IC50 values of 64.92 and 68.01 mg/ml, in that order. Whereas, the leaf extract synthesized AgNPs comparatively shown slightly lower anticancer commotion with the IC50 values of 82.58 and 80.65 mg/ml, respectively. The synthesized AgNPs have also shown higher antibacterial doings against Bacillus subtilis (Gram positive) and Escherichia coli (Gram negative) in comparison to Gentamycin. Hence, the AgNPs obtained by green synthesis can be therapeutically explored against adenocarcinoma and bacterial infections. (C) 2020 Elsevier Ltd. All rights reserved. Selection and peer-review under responsibility of the scientific committee of the International Conference on Advanced Materials Behavior and Characterization.

Automated summary

Plant extracts are used for green production of nanoparticles, with the potential to reduce metals and exhibit anticancer and antibacterial properties. The synthesized silver nanoparticles have demonstrated significant anticancer and antibacterial activities, suggesting therapeutic potential against cancer and bacterial infections.