4.6 Article

Preparation and characterization of glycopolymers with biphenyl spacers via Suzuki coupling reaction

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 19, Issue 20, Pages 4474-4477

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ob00617g

Keywords

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Funding

  1. JSPS KAKENHI [19K05042]
  2. Kurita Water and Environment Foundation
  3. Shiraishi Scientific Research Fund of Fukuoka University [SK2001]
  4. Central Research Institute of Fukuoka University [175009, 207103]
  5. Grants-in-Aid for Scientific Research [19K05042] Funding Source: KAKEN

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Poly(vinylbiphenyl)s bearing glycoside ligands at the side chains were prepared using the Suzuku coupling reaction. The effects of glycoside reactant concentration, halide species, glycoside species, and catalyst species on the incorporation of glycoside ligand into the polymer were investigated. The obtained glycopolymers exhibited specific binding to proteins corresponding to the glycoside ligands and showed fluorescent properties due to the biphenyl spacers formed during the Suzuki coupling reaction.
Poly(vinylbiphenyl)s bearing glycoside ligands at the side chains were prepared using the Suzuku coupling reaction. Effects of glycoside reactant concentration, halide species, glycoside species, and catalyst species on the incorporation of glycoside ligand into the polymer were investigated. The obtained glycopolymers exhibited specific binding to proteins corresponding to the glycoside ligands. In addition, the biphenyl spacers formed by the Suzuki coupling reaction in the glycopolymer were fluorescent, whereas the polymer precursor was not.

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