4.7 Article

Acyl fluorides as direct precursors to fluoride ketyl radicals: reductive deuteration using SmI2 and D2O

Journal

CHEMICAL COMMUNICATIONS
Volume 57, Issue 42, Pages 5195-5198

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc01381e

Keywords

-

Ask authors/readers for more resources

A highly chemoselective reductive deuteration of acyl fluorides using SmI2 and D2O as the deuterium source has been developed, providing alpha,alpha-dideuterio alcohols with exceptional levels of deuterium incorporation. This method introduces acyl fluorides as attractive radical precursors for the generation of reactive acyl-type fluoride ketyls, which should have widespread application in synthetic strategies involving single electron transfer processes.
A highly chemoselective reductive deuteration of acyl fluorides to provide alpha,alpha-dideuterio alcohols with exquisite levels of deuterium incorporation was developed using SmI2 and D2O as the deuterium source. This method introduces acyl fluorides as attractive radical precursors for the generation of reactive acyl-type fluoride ketyls that should find widespread application in many synthetic strategies involving single electron transfer processes.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available