Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 42, Pages 5195-5198Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc01381e
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A highly chemoselective reductive deuteration of acyl fluorides using SmI2 and D2O as the deuterium source has been developed, providing alpha,alpha-dideuterio alcohols with exceptional levels of deuterium incorporation. This method introduces acyl fluorides as attractive radical precursors for the generation of reactive acyl-type fluoride ketyls, which should have widespread application in synthetic strategies involving single electron transfer processes.
A highly chemoselective reductive deuteration of acyl fluorides to provide alpha,alpha-dideuterio alcohols with exquisite levels of deuterium incorporation was developed using SmI2 and D2O as the deuterium source. This method introduces acyl fluorides as attractive radical precursors for the generation of reactive acyl-type fluoride ketyls that should find widespread application in many synthetic strategies involving single electron transfer processes.
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