4.8 Article

Thermodynamics and kinetics of the amyloid-β peptide revealed by Markov state models based on MD data in agreement with experiment

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Summary: The article discusses the conformational and thermodynamic properties of disordered proteins and proposes a method to describe the transition rates between different states using kinetic ensembles. By developing a Markov state model, the kinetic ensemble of A beta 42 is studied, revealing characteristics of state transitions on the microsecond timescale.

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