Journal
FLY
Volume 11, Issue 4, Pages 253-259Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/19336934.2017.1321181
Keywords
Bloom syndrome helicase; chromosome 4; crossover patterning; meiosis; recombination
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Funding
- NIGMS NIH HHS [R35 GM118127] Funding Source: Medline
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Drosophila melanogaster chromosome 4 is an anomaly because of its small size, chromatin structure, and most notably its lack of crossing over during meiosis. Earlier ideas about the absence of crossovers on 4 hypothesize that these unique characteristics function to prevent crossovers. Here, we explore hypotheses about the absence of crossovers on 4, how these have been addressed, and new insights into the mechanism behind this suppression. We review recently published results that indicate that global crossover patterning, in particular the centromere effect, make a major contribution to the prevention of crossovers on 4.
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