Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 44, Pages 5462-5465Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc00793a
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- CSIR, New Delhi
- CSIR-IICB
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The cyclisation reactions between tert-butyl propargyl carbonates and 2-aminotosyl benzamides or sulphonamides catalysed by Pd(0) deliver key components of biologically active compounds, 1,4-benzodiazepin-5-ones or sultam derivatives. However, propargyl carbonates substituted at acetylenic carbon are required for the stereoselective formation of the products with 2-amino benzamides/sulphonamides.
The Pd(0) catalysed cyclisation reactions between tert-butyl propargyl carbonates and 2-aminotosyl benzamides or sulphonamides deliver 1,4-benzodiazepin-5-ones or sultam derivatives, key components of many biologically active compounds. But 2-amino benzamides/sulphonamides require propargyl carbonates substituted at acetylenic carbon to undergo the reaction resulting in the stereoselective formation of the said products.
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