Solubility of an antiarrhythmic drug (amiodarone hydrochloride) in supercritical carbon dioxide: Experimental and modeling

Solubility measurement of solid solute components in supercritical carbon dioxide (SC-CO2) provides essential information for forming pharmaceutical particles of smaller size with a desired size distribution, so as to achieve a better dissolution rate. In this study, for the first time, solubility of amiodarone hydrochloride (AMH) in SC-CO2 was determined using a static method at pressures and temperatures ranging within 12-30 MPa and 313.2-343.2 K, respectively. Under the applied conditions, molar solubilities were obtained in the range of 2.510 x 10(-5) to 1.012 x 10(-3). For correlating the drug solubility in SC-CO2, three of the most widely applied groups of models, namely semi-empirical density-based approaches, equations of state (EoSs), and regular solution models, were used. Statistical analysis of the results showed the superiority of the Peng-Robinson's model over other models for estimating the solubility of AMH based on experimental data. (C)2017 Elsevier B.V. All rights reserved.