Journal
ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY
Volume 27, Issue 2, Pages 84-90Publisher
MEDICAL TRIBUNE INC
DOI: 10.5761/atcs.oa.20-00090
Keywords
non-small-cell lung cancer; prognosis; platelet; albumin; platelet to albumin ratio
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The study demonstrated that the platelet to albumin ratio (PAR) is a predictive biomarker for survival outcomes in patients with non-small-cell lung cancer (NSCLC), and it serves as an independent prognostic factor. Notably, higher values of PAR were associated with poor survival outcomes.
Objective: The purpose of this study was to evaluate the predictive power of the platelet to albumin ratio (PAR) on survival outcomes of patients with non-small-cell lung cancer (NSCLC). Patients and Methods: In all, 198 patients with NSCLC were recruited. The X-tile software was performed to identify the optimal cutoff values for PAR, platelet to lymphocyte ratio (PLR), and neutrophil to lymphocyte ratio (NLR). The Kaplan-Meier method, univariate and multivariate analyses Cox regression were used to analyze the prognostic factors for overall survival (OS). Results: In all, 198 patients were enrolled, containing 146 (73.7%) men and 52 (26.3%) women. The optimal cutoff values for PAR, PLR, and NLR were 8.8x10(9), 147.7, and 3.9, respectively. Patients with PAR > 8.8 x 10(9) (P < 0.001), PLR > 147.7 (P < 0.001), and NLR >3.9 (P = 0.007) were associated with poor OS. Multivariate analyses found that PAR was an independent predictor in NSCLC patients (hazard ratio [HR]: 4.604, 95% confidence interval [CI]: 2.557-8.290, P < 0.001). Conclusion: Preoperative PAR is a useful and potential prognostic biomarker in NSCLC patients who have received primary resection.
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