Related references
Note: Only part of the references are listed.Tyrosine kinase inhibitors in chronic myeloid leukaemia and emergent cardiovascular disease
Darryl Leong et al.
HEART (2021)
Left ventricular hypertrophy and hypertension
Mehmet Yildiz et al.
PROGRESS IN CARDIOVASCULAR DISEASES (2020)
Sympathetic Activation in Hypertension: Importance of the Central Nervous System
Yoshitaka Hirooka
AMERICAN JOURNAL OF HYPERTENSION (2020)
Resident cardiac macrophages: crucial modulators of cardiac (patho)physiology
M. Sansonetti et al.
BASIC RESEARCH IN CARDIOLOGY (2020)
Rho-family GTPase 1 (Rnd1) is a biomechanical stress-sensitive activator of cardiomyocyte hypertrophy
Annika Kluge et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2019)
RhoA inhibitor-eluting stent attenuates restenosis by inhibiting YAP signaling
Chen Huang et al.
JOURNAL OF VASCULAR SURGERY (2019)
RhoA as a Key Regulator of Innate and Adaptive Immunity
Matthias Bros et al.
CELLS (2019)
Activation of RHOA-VAV1 signaling in angioimmunoblastic T-cell lymphoma
M. Fujisawa et al.
LEUKEMIA (2018)
RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis
Jose R. Cortes et al.
CANCER CELL (2018)
The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC
Stefan Frantz et al.
EUROPEAN JOURNAL OF HEART FAILURE (2018)
Inhibition of RhoA and mTORC2/Rictor by Fingolimod (FTY720) induces p21-activated kinase 1, PAK-1 and amplifies podosomes in mouse peritoneal macrophages
Wei Chen et al.
IMMUNOBIOLOGY (2018)
Regulation of RhoA GTPase and various transcription factors in the RhoA pathway
Jae-Gyu Kim et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2018)
Mechanisms of physiological and pathological cardiac hypertrophy
Michinari Nakamura et al.
NATURE REVIEWS CARDIOLOGY (2018)
Left-Ventricular Energetics in Pulmonary Arterial Hypertension-Induced Right-Ventricular Hypertrophic Failure
June-Chiew Han et al.
FRONTIERS IN PHYSIOLOGY (2018)
Dasatinib: A Review in Chronic Myeloid Leukaemia and Ph plus Acute Lymphoblastic Leukaemia
Gillian M. Keating
DRUGS (2017)
Tyr42 phosphorylation of RhoA GTPase promotes tumorigenesis through nuclear factor (NF)-κB
Jae-Gyu Kim et al.
FREE RADICAL BIOLOGY AND MEDICINE (2017)
Cardiac inflammation in genetic dilated cardiomyopathy caused by MYBPC3 mutation
Thomas L. Lynch et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2017)
Geranylgeranyl diphosphate synthase inhibition induces apoptosis that is dependent upon GGPP depletion, ERK phosphorylation and caspase activation
Sherry S. Agabiti et al.
CELL DEATH & DISEASE (2017)
Carbon nanotube-composite hydrogels promote intercalated disc assembly in engineered cardiac tissues through β1-integrin mediated FAK and RhoA pathway
Hongyu Sun et al.
ACTA BIOMATERIALIA (2017)
Myozap Deficiency Promotes Adverse Cardiac Remodeling via Differential Regulation of Mitogen-activated Protein Kinase/Serum-response Factor and β-Catenin/GSK-3β Protein Signaling
Ashraf Yusuf Rangrez et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Endothelial Actions of ANP Enhance Myocardial Inflammatory Infiltration in the Early Phase After Acute Infarction
Wen Chen et al.
CIRCULATION RESEARCH (2016)
RhoA/Rho-Kinase in the Cardiovascular System
Hiroaki Shimokawa et al.
CIRCULATION RESEARCH (2016)
Mouse macrophage polarity and ROCK1 activity depend on RhoA and non-apoptotic Caspase 3
Yianzhu Liu et al.
EXPERIMENTAL CELL RESEARCH (2016)
Central Angiotensin-II Increases Blood Pressure and Sympathetic Outflow via Rho Kinase Activation in Conscious Rabbits
Peter R. Pellegrino et al.
HYPERTENSION (2016)
Monocyte and macrophage contributions to cardiac remodeling
Maarten Hulsmans et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2016)
Immune Cell and Other Noncardiomyocyte Regulation of Cardiac Hypertrophy and Remodeling
Ryan A. Frieler et al.
CIRCULATION (2015)
Exaggerated Inflammation and Monocytosis Associate With Diastolic Dysfunction in Heart Failure With Preserved Ejection Fraction: Evidence of M2 Macrophage Activation in Disease Pathogenesis
Nadezhda Glezeva et al.
JOURNAL OF CARDIAC FAILURE (2015)
Immunoadsorption therapy in dilated cardiomyopathy
Stephan B. Felix et al.
EXPERT REVIEW OF CARDIOVASCULAR THERAPY (2015)
Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry
Xiaodong Feng et al.
CANCER CELL (2014)
IκB Kinase γ/Nuclear Factor-κB-Essential Modulator (IKKγ/NEMO) Facilitates RhoA GTPase Activation, which, in Turn, Activates Rho-associated Kinase ( ROCK) to Phosphorylate IKKβ in Response to Transforming Growth Factor (TGF)-β1
Hee-Jun Kim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Innate immunity and cardiomyocytes in ischemic heart disease
Li Lin et al.
LIFE SCIENCES (2014)
Atrial natriuretic peptide: An old hormone or a new cytokine?
Paolo De Vito
PEPTIDES (2014)
RhoA signaling in cardiomyocytes protects against stress-induced heart failure but facilitates cardiac fibrosis
Jessica Lauriol et al.
SCIENCE SIGNALING (2014)
Mechanistic insight into GPCR-mediated activation of the microtubule-associated RhoA exchange factor GEF-H1
David Meiri et al.
NATURE COMMUNICATIONS (2014)
Rho-kinase: regulation, (dys) function, and inhibition
Ehsan Amin et al.
BIOLOGICAL CHEMISTRY (2013)
Dysbindin is a potent inducer of RhoA-SRF-mediated cardiomyocyte hypertrophy
Ashraf Yusuf Rangrez et al.
JOURNAL OF CELL BIOLOGY (2013)
A Novel Paradigm for Heart Failure With Preserved Ejection Fraction Comorbidities Drive Myocardial Dysfunction and Remodeling Through Coronary Microvascular Endothelial Inflammation
Walter J. Paulus et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2013)
Rational Design of Small Molecule Inhibitors Targeting RhoA Subfamily Rho GTPases
Xun Shang et al.
CHEMISTRY & BIOLOGY (2012)
YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy
Alexander von Gise et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
The cAMP-responsive Rap1 Guanine Nucleotide Exchange Factor, Epac, Induces Smooth Muscle Relaxation by Down-regulation of RhoA Activity
Bartosz J. Zieba et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
RhoA protects the mouse heart against ischemia/reperfusion injury
Sunny Yang Xiang et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Role of YAP/TAZ in mechanotransduction
Sirio Dupont et al.
NATURE (2011)
The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins
Christophe Guilluy et al.
NATURE CELL BIOLOGY (2011)
Myozap, a Novel Intercalated Disc Protein, Activates Serum Response Factor-Dependent Signaling and Is Required to Maintain Cardiac Function In Vivo
Thalia S. Seeger et al.
CIRCULATION RESEARCH (2010)
Structure and Function of Heterotrimeric G Protein-Regulated Rho Guanine Nucleotide Exchange Factors
Mohamed Aittaleb et al.
MOLECULAR PHARMACOLOGY (2010)
Revisited and Revised: Is RhoA Always a Villain in Cardiac Pathophysiology?
Shigeki Miyamoto et al.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2010)
Regulation of RhoGEF proteins by G12/13-coupled receptors
Sandra Siehler
BRITISH JOURNAL OF PHARMACOLOGY (2009)
INFLAMMASOMES ARE DIFFERENTIALLY EXPRESSED IN CARDIOVASCULAR AND OTHER TISSUES
Y. Yin et al.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY (2009)
The mDial Formin Is Required for Neutrophil Polarization, Migration, and Activation of the LARG/RhoA/ROCK Signaling Axis during Chemotaxis
Yongquan Shi et al.
JOURNAL OF IMMUNOLOGY (2009)
Hypertension and Myocardial Ischemia
Brian P. Murphy et al.
MEDICAL CLINICS OF NORTH AMERICA (2009)
p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities
X-Y Yang et al.
ONCOGENE (2009)
The δ isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload
Johannes Backs et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Effects of a Rho kinase inhibitor on pressure overload induced cardiac hypertrophy and associated diastolic dysfunction
Arintaya Phrommintikul et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2008)
P2Y6 receptor-Gα12/13 signalling in cardiomyocytes triggers pressure overload-induced cardiac fibrosis
Motohiro Nishida et al.
EMBO JOURNAL (2008)
Rho family GTPase modification and dependence on CAAX motif-signaled posttranslational modification
Patrick J. Roberts et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Focal Adhesion Kinase as a RhoA-activable Signaling Scaffold Mediating Akt Activation and Cardiomyocyte Protection
Dominic P. Del Re et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Small GTP-binding proteins and their regulators in cardiac hypertrophy
Frank Lezoualc'h et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2008)
Disruption of ROCK1 gene attenuates cardiac dilation and improves contractile function in pathological cardiac hypertrophy
Jianjian Shi et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2008)
Serum-induced phosphorylation of the serum response factor coactivator MKL1 by the extracellular signal-regulated kinase 1/2 pathway inhibits its nuclear localization
Susanne Muehlich et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Gαq directly activates p63RhoGEF and trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain
Rafael J. Rojas et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
The A-kinase anchoring protein (AKAP)-Lbc-signaling complex mediates α1 adrenergic receptor-induced cardiomyocyte hypertrophy
Aline Appert-Collin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
GEFs and GAPs: Critical elements in the control of small G proteins
Johannes L. Bos et al.
CELL (2007)
RhoA/Rho kinase up-regulate bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis
Dominic P. Del Re et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Pressor response induced by central angiotensin II is mediated by activation of Rho/Rho-kinase pathway via AT1 receptors
Yoji Sagara et al.
JOURNAL OF HYPERTENSION (2007)
Evolution of the Rho family of Ras-like GTPases in eukaryotes
Anthony Boureux et al.
MOLECULAR BIOLOGY AND EVOLUTION (2007)
Rho kinase inhibition improves endothelial function in human subjects with coronary artery disease
Anju Nohria et al.
CIRCULATION RESEARCH (2006)
The role of geranylgeranylated proteins in human mesangial cell proliferation
A. Khwaja et al.
KIDNEY INTERNATIONAL (2006)
High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor
Gregor Theilmeier et al.
CIRCULATION (2006)
Regulation of cardiac hypertrophy by intracellular signalling pathways
Joerg Heineke et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)
Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis
Ying-Min Zhang et al.
FASEB JOURNAL (2006)
Rho kinase polymorphism influences blood pressure and systemic vascular resistance in human twins - Role of heredity
TM Seasholtz et al.
HYPERTENSION (2006)
Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I
KT Lane et al.
JOURNAL OF LIPID RESEARCH (2006)
The Rac and Rho hall of fame - A decade of hypertrophic signaling hits
JH Brown et al.
CIRCULATION RESEARCH (2006)
Physiological role of ROCKs in the cardiovascular system
K Noma et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2006)
p190-RhoGAP as an integral component of the Tiam1/Rac1-induced downregulation of Rho
U Herbrand et al.
BIOLOGICAL CHEMISTRY (2006)
Rho kinases in cardiovascular physiology and pathophysiology
G Loirand et al.
CIRCULATION RESEARCH (2006)
Rho GEF Lsc is required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils
SA Francis et al.
BLOOD (2006)
Plasma membrane organization is essential for balancing competing pseudopod- and uropod-promoting signals during neutrophil polarization and migration
S Bodin et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
RhoA/ROCK signaling is critical to FAK activation by cyclic stretch in cardiac myocytes
AS Torsoni et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2005)
Neuroendocrine profiling of humans receiving cardiac allografts
T Ogawa et al.
JOURNAL OF HEART AND LUNG TRANSPLANTATION (2005)
Lysophosphatidic acid-mediated augmentation of cardiomyocyte lipoprotein lipase involves actin cytoskeleton reorganization
T Pulinilkunnil et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2005)
Tissue-specific mRNA expression profiles of human toll-like receptors and related genes
M Nishimura et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2005)
Protein farnesylation: Implications for normal physiology, malignant transformation, and cancer therapy
SM Sebti
CANCER CELL (2005)
The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA
S Lutz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Receptors coupled to heterotrimeric G proteins of the G12 family
NA Riobo et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2005)
PKC mediates cyclic stretch-induced cardiac hypertrophy through Rho family GTPases and mitogen-activated protein kinases in cardiomyocytes
J Pan et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2005)
Left ventricular hypertrophy in hypertension: Its arrhythmogenic potential
T Kahan et al.
HEART (2005)
Lysophosphatidic acid induces hypertrophy of neonatal cardiac myocytes via activation of Gi and Rho
R Hilal-Dandan et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2004)
PKC-α regulates cardiac contractility and propensity toward heart failure
JC Braz et al.
NATURE MEDICINE (2004)
Rho-kinase, a potential therapeutic target for the treatment of hypertension
Y Hirooka et al.
DRUG NEWS & PERSPECTIVES (2004)
Hypertension and RhoA/Rho-kinase signaling in the vasculature - Highlights from the recent literature
DL Lee et al.
HYPERTENSION (2004)
Calcium-calcineurin signaling in the regulation of cardiac hypertrophy
BJ Wilkins et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Long-term inhibition of Rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo - Effect on endothelial NAD(P)H oxidase system
M Higashi et al.
CIRCULATION RESEARCH (2003)
Oxygen free radical release in human failing myocardium is associated with increased activity of Rac1-GTPase and represents a target for statin treatment
C Maack et al.
CIRCULATION (2003)
Initiation and transduction of stretch-induced RhoA and Rac1 activation through caveolae - Cytoskeletal regulation of ERK translocation
S Kawamura et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Rho/Rho-kinase pathway in brain stem contributes to blood pressure regulation via sympathetic nervous system - Possible involvement in neural mechanisms of hypertension
K Ito et al.
CIRCULATION RESEARCH (2003)
The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI
T Yamashita et al.
NATURE NEUROSCIENCE (2003)
RhoA is highly up-regulated in the process of early heart development of the chick and important for normal embryogenesis
M Kaarbo et al.
DEVELOPMENTAL DYNAMICS (2003)
Redox-dependent downregulation of Rho by Rac
AS Nimnual et al.
NATURE CELL BIOLOGY (2003)
Gα12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF
N Suzuki et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Chronic inhibition of Rho kinase blunts the process of left ventricular hypertrophy leading to cardiac contractile dysfunction in hypertension-induced heart failure
S Satoh et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2003)
Cardiac hypertrophy: The good, the bad and the ugly
N Frey et al.
ANNUAL REVIEW OF PHYSIOLOGY (2003)
Gα12/13 mediates α1-adrenergic receptor-induced cardiac hypertrophy
Y Maruyama et al.
CIRCULATION RESEARCH (2002)
Pharmacological potentiation of natriuretic peptide limits polymorphonuclear neutrophil-vascular cell interactions
EM Mtairag et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2002)
Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P2/LPB2/EDG-5 and S1P3/LPB3/EDG-3
I Ishii et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Inhibition of p38 MAPK activation via induction of MKP-1 -: Atrial natriuretic peptide reduces TNF-α-induced actin polymerization and endothelial permeability
AK Kiemer et al.
CIRCULATION RESEARCH (2002)
Impaired cardiac hypertrophic response in calcineurin Aβ-deficient mice
OF Bueno et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
PKCα regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase1/2 (ERK1/2)
JC Braz et al.
JOURNAL OF CELL BIOLOGY (2002)
Impact of HMG CoA reductase inhibition on small GTPases in the heart
U Laufs et al.
CARDIOVASCULAR RESEARCH (2002)
Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Gαq/Gα11 in cardiomyocytes
N Wettschureck et al.
NATURE MEDICINE (2001)
Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA
F Charron et al.
GENES & DEVELOPMENT (2001)
RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity
WT Arthur et al.
MOLECULAR BIOLOGY OF THE CELL (2001)
Protein kinase C-α signals Rho-guanine nucleotide dissociation inhibitor phosphorylation and Rho activation and regulates the endothelial cell barrier function
D Mehta et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
ABC of hypertension - The pathophysiology of hypertension
G Beevers et al.
BRITISH MEDICAL JOURNAL (2001)
Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: Lessons from mechanism and bench-to-bedside translational studies
SM Sebti et al.
ONCOGENE (2000)
Farnesyltransferase and geranylgeranyltransferase I inhibitors in cancer therapy: important mechanistic and bench to bedside issues
SM Sebti et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2000)