Journal
CHINESE JOURNAL OF ORGANIC CHEMISTRY
Volume 41, Issue 2, Pages 455-470Publisher
SCIENCE PRESS
DOI: 10.6023/cjoc202009009
Keywords
dearomatization reactions; aryne; N-heteroaromatics; multicomponent reaction; cycloaddition reaction
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Funding
- Fundamental Research Funds for the Central Universities at Beijing University of Chemical Technology [XK1802-6]
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Dearomatization reaction is a popular research area in organic chemistry, which can build highly functionalized three-dimensional molecules from aromatic compounds. This review discusses the mechanisms and various synthetic protocols of dearomatization reactions involving arynes, as well as provides insights and outlooks on this rapidly developing field.
Dearomatization reaction is one of the most popular research areas in organic chemistry. It could build highly functionalized three-dimensional molecules from readily available planar aromatic compounds. In recent years, arynes as reactive intermediates have been extensively investigated in dearomatization reactions, and a series of synthetic protocols have been reported. The mechanisms of the dearomatization reaction of azaarenes with arynes, the [4+2] cycloaddition dearomatization reactions of arynes with dienes, and the dearomatization of arynes in other pathways are reviewed. The insights and outlooks regarding this rapid developing field are also provided.
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