Parafoveal Microvascular Alterations in Ocular and Non-Ocular Behcet's Disease Evaluated With Optical Coherence Tomography Angiography

PURPOSE. To compare quantitative optical coherence tomography angiography (OCT-A) measurements of the parafoveal microvasculature in retinal capillary plexuses among Behcet uveitis (BU) patients, non-ocular Behcet's disease (NOBD) patients, and healthy volunteers (HVs). METHODS. Sixty-eight subjects were enrolled in this prospective observational cross-sectional study. OCT-A imaging was performed using the Heidelberg Engineering Spectralis OCT. A custom algorithm was developed to calculate the vessel density (VD) in three retinal vascular layers: deep capillary plexus, intermediate capillary plexus, and superficial vascular plexus. The foveal avascular zone (FAZ) and acircularity index were calculated for the whole retinal vascular complex. RESULTS. We analyzed one eye from 21 BU patients (age, 51 +/- 10 years), 23 NOBD patients (age, 48 +/- 14 years), and 22 HVs (age, 44 +/- 13 years). One-way multivariate analysis of covariance showed a statistically significant difference in VD among the three groups when combining the layers after controlling for scan quality (P < 0.001). The VD was lowest in the BU group and highest in the HV group in all layers. The FAZ area was also statistically significant different among the groups (P < 0.005), with the largest FAZ areas in BU patients and smallest FAZ areas in the HV group. However, no statistically significant difference was found for the acircularity index. CONCLUSIONS. The parafoveal microvasculature is affected not only in BU patients but also in NOBD patients. Most deviations in the retinal microcirculation in Beh.et patients were found in the deeper layers of the retina by using the quantitative VD measurement.

Automated summary

The parafoveal microvasculature is affected not only in Behcet uveitis (BU) patients but also in non-ocular Behcet's disease (NOBD) patients. The vessel density (VD) was found to be lowest in the BU group and highest in the healthy volunteers (HV) group in all layers. The foveal avascular zone (FAZ) area was also significantly different among the groups, with the largest FAZ areas in BU patients and smallest FAZ areas in the HV group.