Thiol Disulfide Balance Oxidative Stress and Paraoxonase 1 Activities in Children and Adolescents Aged 6-16 Years with Specific Learning Disorders

Introduction: Specific learning disorders (SLD) are some of the most common neurodevelopmental disorders. The aim of this study is to determine the potential relationship between children with SLD and zinc, copper, paraoxonase 1 (PON1), arylesterase (ARY), ischemia-modified albumin, thiol balance, oxidative stress index, total antioxidant status, total oxidant status, and routine biochemical parameters. Methods: All participants were assessed with the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children. Total oxidant status, total antioxidant status, thiol balance, ischemia modified albumin, paraoxonase 1 activity, arylesterase activity, zinc and copper levels were measured by the spectrophotometric methods. Results: Compared to the control, the SLD group had statistically significantly lower values for PON1 antioxidant enzyme activity (p=.045), ARY antioxidant enzyme activity (p<.001), 25 OH Vitamin D (p=.005), reduced thiol ratio (p=.028), thiol oxidation reduction ratio (p=.01), native thiols (p=.024) and significantly higher values for total oxidant status (p=.017), oxidized thiol ratio (p=.028). Conclusion: The relationship between oxidative stress and SLD diagnosis in our results will be very important if it is supported by further new studies. In this case, evaluation of vitamin D, oxidative stress, antioxidant status and thiol balance may come to the agenda in the diagnosis and treatment of SLD.

Automated summary

The study found that children with Specific Learning Disorders (SLD) have significant abnormalities in oxidative stress, suggesting an important relationship between oxidative stress and SLD diagnosis that may be crucial for future research.