Journal
LAB ON A CHIP
Volume 21, Issue 12, Pages 2453-2463Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1lc00265a
Keywords
-
Categories
Funding
- National Institutes of Health [UG3TR002978, U18TR003778, R01GM132603, R01GM135486, R01HD086325]
- United States Army Medical Research Acquisition Activity [W81XWH-18-1-0242]
- China Scholarship Council
Ask authors/readers for more resources
In this study, a novel acoustofluidic platform was developed to synthesize size-tunable, high-molecular-weight polymeric nanoparticles, overcoming polymer aggregation. The platform achieved multi-step sequential nanoprecipitation and synthesis of core-shell structured nanoparticles, demonstrating potential for expanding microfluidic applications in nanomaterial synthesis.
High-molecular-weight polymeric nanoparticles are critical to increasing the loading efficacy and tuning the release profile of targeted molecules for medical diagnosis, imaging, and therapeutics. Although a number of microfluidic approaches have attained reproducible nanoparticle synthesis, it is still challenging to fabricate nanoparticles from high-molecular-weight polymers in a size and structure-controlled manner. In this work, an acoustofluidic platform is developed to synthesize size-tunable, high-molecular-weight (>45 kDa) poly(lactic-co-glycolic acid)-b-poly(ethylene glycol) (PLGA-PEG) nanoparticles without polymer aggregation by exploiting the characteristics of complete and ultrafast mixing. Moreover, the acoustofluidic approach achieves two features that have not been achieved by existing microfluidic approaches: (1) multi-step (>= 2) sequential nanoprecipitation in a single device, and (2) synthesis of core-shell structured PLGA-PEG/lipid nanoparticles with high molecular weights. The developed platform expands microfluidic potential in nanomaterial synthesis, where high-molecular-weight polymers, multiple reagents, or sequential nanoprecipitations are needed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available