Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 45, Pages 5530-5533Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc00343g
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Funding
- National Natural Science Foundation of China [21772144]
- National Key Research & Development (R&D) Program of China [2020YFA0907903]
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NBDQ is a non-antibody inhibitor probe that is 30 times more sensitive than traditional GLUT1 transportable tracers for cancer cell imaging and tumor detection based on the Warburg effect. It shows significant advantages in tumor selectivity, fluorescence stability, and in vivo biocompatibility, including in xenograft tumor imaging, such as triple-negative breast cancer.
We report a non-antibody GLUT1 inhibitor probe NBDQ that is 30 times more sensitive than the traditional GLUT1 transportable tracer for cancer cell imaging and Warburg effect-based tumor detection. NBDQ reveals significant advantages in terms of tumor selectivity, fluorescence stability and in vivo biocompatibility in xenograft tumor imaging, including triple-negative breast cancer.
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