Journal
FITOTERAPIA
Volume 118, Issue -, Pages 49-55Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2017.02.009
Keywords
Aquilaria sinensis; Chinese agarwood; 2-(2-phenylethyl)chromone; Anti-inflammatory activity; Electronic circular dichroism
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Funding
- National Natural Science Foundation of China [81503227, 81573572, 81530097]
- Program for New Century Excellent Talents in University [NCET-13-0693]
- National Project for Standardization of Chinese Materia Medica [ZYBZH-Y-GD-13]
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Five new 2-(2-phenylethyl)chromone derivatives (1-5), along with eleven known compounds (6-16) were isolated from Chinese agarwood. Their structures were elucidated by spectroscopic data (NMR, UV, IR, and MS) analyses and comparison of their spectroscopic and physical data with the literature values. The absolute configurations of 2-4 were determined by electronic circular dichroism (ECD) calculations. Compounds 2-4, 11, 12, and 15 exhibited significant inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 cells with IC50 values in the range 1.6-7.3 mu M. (C) 2017 Elsevier B.V. All rights reserved.
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