Journal
FITOTERAPIA
Volume 123, Issue -, Pages 44-50Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2017.09.013
Keywords
Salvia tiliifolia; Neo-clerodane diterpenoids; Neurotrophic activities; Cytotoxicity
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Funding
- National Natural Science Foundation of China [21402212, U1502223]
- Yunnan Applied Basic Research Project [2016FB140]
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Five new neo-clerodane diterpenoids, tiliifolins A-E (1-5), along with ten known ones, were isolated from the aerial part of Salvia tiliifolia. Their structures were proposed based on 1D and 2D NMR spectroscopic data analysis. All new compounds were evaluated for their neurotrophic activity on PC12 cells and cytotoxicity against five human cancer cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW480), and compound 5 showed statistically significant neuroprotective effect in vitro assay.
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