Journal
FITOTERAPIA
Volume 118, Issue -, Pages 27-31Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2017.02.003
Keywords
Dasymaschalon rostratum; Phenylpropanoid; 6H-dibenzo[b,d]pyran-6-one; Anti-HIV-1 activity
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Funding
- International S&T cooperation Program of China (ISTCP) [2014DFA40850]
- National Natural Science Foundation of China [21362009, 81360478]
- Natural Science Foundation of Hainan Province of innovative research team project [2016CXT007]
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Three new phenylpropanoid derivatives, dasymaroacid A (1), dasymaroesters B and C (2 and 3), and one new polyoxygenated 6H-dibenzo[b,d]pyran-6-one derivative dasymarolactone D (4), together with seven known compounds (5-11), were isolated from the stems of Dasymaschalon rostratum Merr. Compounds 1 and 2 are unusual phenylpropanoid derivatives with a polymethyl substituted cyclopentene conjugated diketone as a substituent, and 3 is a unique cinnamic acid detective with a polymethyl substituted cyclohexene conjugated triketone as a substituent. Their structures were elucidated by extensive spectroscopic methods and chemical method, and 4 was further confirmed by the single crystal X-ray diffraction method. Compounds 1-4 and 7 showed weak anti HIV-1 activities with EC50 values ranged from 16.44 to 25.91 mu M. (C) 2017 Elsevier B.V. All rights reserved.
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